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The 2007 International Symposium on Bioinformatics Research and Appli- tions (ISBRA 2007), was held on May 7-10, 2007 at Georgia State University in Atlanta, Georgia. The ISBRA symposium provides a forum for the exchange of ideas and results among researchers,developers, and practitioners working on all aspects of bioinformatics and computational biology and their applications. ISBRA is the successor of the International Workshop on Bioinformatics - search and Applications (IWBRA), held May 22-25, 2005 in Atlanta, GA and May 28-31, 2006 in Reading, UK, in conjunction with the International Conf- ence on Computational Science. This year, 146 papers were submitted in response to the call for papers. F- lowing a rigorous review process, the Program Committee selected 55 papers for publication in the proceedings and oral presentations at the symposium. The topics of selected papers covereda wide range of topics, including clustering andclassi?cation,geneexpressionanalysis,genenetworks,genomeanalysis,- tif ?nding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools. In addition to contributed talks,the ISBRA 2007technical programincluded several tutorials and poster sessions, and features invited keynote talks by three distinguished speakers. Ming Li from University of Waterloo spoke on modern homologysearch,Laura L. Elnitski from the National Human Genome Research Institute spoke on bidirectional promoters in the human genome, and Mark BorodovskyfromGeorgiaInstituteofTechnologyspokeonabinitiogene?nding.

Mathematical statistics --- Molecular biology --- Computer science --- Programming --- Information systems --- patroonherkenning --- factoranalyse --- bio-informatica --- informatica --- database management --- moleculaire biologie

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This book constitutes the refereed proceedings of the 5th International Symposium on Bioinformatics Research and Applications, ISBRA 2009, held in Fort Lauderdale, FL, USA, in May 2009. The 26 revised full papers presented together four invited papers were carefully reviewed and selected from a total of 55 submissions. The papers cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

Mathematical statistics --- Biomathematics. Biometry. Biostatistics --- Molecular biology --- Biology --- Programming --- Information systems --- Artificial intelligence. Robotics. Simulation. Graphics --- Computer. Automation --- patroonherkenning --- factoranalyse --- bio-informatica --- biologie --- grafische vormgeving --- informatica --- biometrie --- database management --- KI (kunstmatige intelligentie) --- moleculaire biologie