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Book
ISBN: 128278742X 9786612787423 0309151309 0309157277 Year: 2010 Publisher: Washington, DC : National Academies Press,
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"Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process."--Publisher's description.
Book
ISBN: 0309163242 9786612976056 1282976052 0309163250 9780309163248 9780309163255 9781282976054 0309187001 Year: 2011 Publisher: Washington, D.C. : National Academies Press,
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In 2010 the Institute of Medicine (IOM) recommended a framework for the evaluation of biomarkers in the chronic disease setting. Published in the book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease, the framework is intended to bring consistency and transparency to the previously disparate process of biomarker evaluation. Following the book's release, the IOM convened a 2-day discussion forum in Washington, DC, in order to provide an opportunity for stakeholders to learn about, react to, and discuss the book. Presentations reviewed the authoring committee's work process, recommendations, and provided perspectives on the book from the point of view of participants. Thomas Fleming, professor of biostatistics and statistics at the University of Washington, gave a keynote presentation on the critical issues in the validation of surrogate endpoints, a specific use of a biomarker. The present volume recounts the discussion forum proceedings, focusing in turn on each represented sector. A summary of Dr. Fleming's presentation then sets the committee's recommendations within the context of biomarker utilization. Lastly, this summary examines the main themes raised by stakeholders, and the challenges and opportunities presented to stakeholders by the book's recommendations.--
Markers, Biochemical --- Biochemical markers. --- Biologic markers --- Biological markers --- Biomarkers --- Biochemistry --- Indicators (Biology)
Book
ISBN: 0309305594 1283151731 9786613151735 0309163226 9780309163224 9781283151733 6613151734 0309163218 9780309163217 9780309305594 Year: 2011 Publisher: Washington, D.C. : National Academies Press,
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"One way scientists are working to overcome challenges in cancer treatment and improve cancer care is through nanotechnology. Nanotechnology, engineered materials that make use of the unique physical properties, presents a new array of medical prospects that will revolutionize cancer prevention, diagnosis, and treatment practices. Giving new hope to patients, practitioners, and researchers alike, nanotechnology has the potential to translate recent discoveries in cancer biology into clinical advances in oncology. While public investments in nanotechnology for cancer continue to increase, medical products based on nanotechnology are already on the market. The National Cancer Policy forum held a workshop July 12-13, 2010, to explore challenges in the use of nanotechnology in oncology. Nanotechnology and Oncology evaluates the ongoing discussion on the role of nanotechnology in cancer as it relates to risk management, treatment, and regulatory policy. Assessments on nanomedicine and the physical properties of nanomaterials were presented during the workshop, along with an appraisal of the current status of research and development efforts."--Publisher's Website.
Book
ISBN: 1283636409 0309224195 Year: 2012 Publisher: Washington, D.C. : National Academies Press,
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Genomics --- Genetic translation --- Biomolecules --- Bioinformatics --- Biotechnology. --- Data mining --- Technology. --- Data processing. --- Analysis.
Book
ISBN: 1282008048 9786612008047 0309128684 9780309128681 9781282008045 9780309128674 0309128676 0309177472 Year: 2009 Publisher: Washington, D.C. : National Academies Press,
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Cancer --- Clinical trials. --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Treatment --- Research --- National Cancer Institute (U.S.) --- NCI --- N.C.I. --- United States. --- National Institutes of Health (U.S.). --- National Cancer Program --- National Cancer Institute of the USA --- US National Cancer Institute --- Instituto Nacional del Cáncer (U.S.) --- U.S. National Cancer Institute
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