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Engelse taal ; thesissen

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Worldwide efforts to promote greater lithium use for mood disorders have increased the need for evidence-based guidance addressing key questions related to initiation, monitoring and adverse effect management. This practical handbook provides clinicians with a detailed explanation of lithium's renal journey, how this informs our understanding of polyuria pathogenesis and how medications or hyponatremia can alter lithium clearance. Covering efficacy, pharmacokinetics, toxicity, discontinuation, and use in special patient groups including pregnant and breastfeeding women, older or younger patients, each section also provides a detailed background for its suggested logical approach to managing lithium's renal and other adverse effects. Using the latest data, the book outlines rationales for specific management decisions, and prioritizes options to provide clinical guidance on the best course of action. Colour-coded lists and tables, bulleted text, and diagrams illustrate important points throughout, helping to make information accessible and easy-to-digest. An essential resource for mental health professionals worldwide.

Lithium. --- Lithium --- Psychotropic drugs. --- Psychopharmacology. --- Bipolar disorder --- Therapeutic use. --- Treatment.

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Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.

Clozapine --- Antipsychotic Agents --- Schizophrenia --- administration & dosage --- therapeutic use --- adverse effects --- drug therapy --- Neuroleptiques --- Schizophrénie --- Effets secondaires. --- Thérapeutique. --- Modes d'administration. --- Chimiothérapie. --- Clozapine - administration & dosage --- Clozapine - therapeutic use --- Clozapine - adverse effects --- Schizophrenia - drug therapy --- Antipsychotic Agents. --- administration & dosage. --- therapeutic use. --- adverse effects. --- drug therapy. --- Modes d'administration --- Schizophrénie --- Thérapeutique. --- Chimiothérapie. --- Clozapine.