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Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications

Natural products --- Metathesis (Chemistry)

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In the framework of total hip arthroplasty (THA), there is today in clinical practice no well-defined short-term strategy to prevent impaired outcomes and implant failures. Indeed, reported high revision rate and implant failures are based on cohort studies which take a long follow-up time to generate useful data while patients at risks are not yet targeted. Moreover, cohort studies focus on a group of patients receiving a similar treatment to draw general conclusions but not on an individual basis, although response to a treatment can be patient-dependent. There is therefore a need for an innovative approach to establish a short-term patient evaluation and on an individual level.The goal of the project is hence to develop an integrated workflow and a personalized physiotherapy care plan to diagnose and remediate gait deviations following a primary total hip arthroplasty. This will prevent aberrant loading of the hip joint with consequent implant failure. Innovative in our approach is the integrative use of state-of-the-art biomechanical assessment methods; more specific clinical gait analysis, and musculoskeletal modelling techniques supplemented with state of the art techniques for muscle force measurements. The project results are therefore not only useful as a new screening tool to monitor gait aberrations in THA, they also allow to estimate the efficacy of treatment protocols aiming to improve gait function and consequently normalizeimplant loading.