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Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.

Mutagenesis. --- Diseases --- Mice --- Genomes. --- Animal models. --- Genetics. --- Genetics --- Genomics --- Haploidy --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents --- Animal disease models --- Disease models, Animal --- Animal models in research --- Medicine, Comparative --- Medicine, Experimental --- Pathology, Comparative --- Pathology, Experimental --- Mutation (Biology) --- Radiogenetics --- Teratogenesis --- Toxicology. --- Medicine. --- Human genetics. --- Biochemistry. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Human Genetics. --- Medical Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Composition --- Toxicology --- Health Workforce --- Pharmacology. --- Molecular biology. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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