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Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-

Serotonin --- Memory disorders --- Memory --- Biochemical Processes --- Tryptamines --- Neurobehavioral Manifestations --- Autacoids --- Cell Physiological Processes --- Learning --- Neurologic Manifestations --- Inflammation Mediators --- Chemical Processes --- Behavior and Behavior Mechanisms --- Indoles --- Mental Processes --- Biochemical Phenomena --- Biogenic Monoamines --- Cell Physiological Phenomena --- Phenomena and Processes --- Biological Factors --- Chemical Phenomena --- Signs and Symptoms --- Psychiatry and Psychology --- Nervous System Diseases --- Psychological Phenomena and Processes --- Biogenic Amines --- Heterocyclic Compounds, 2-Ring --- Pathological Conditions, Signs and Symptoms --- Heterocyclic Compounds --- Amines --- Diseases --- Chemicals and Drugs --- Organic Chemicals --- Memory Disorders --- Signal Transduction --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Chemotherapy --- Serotonin. --- Memory. --- Chemotherapy. --- Retention (Psychology) --- Intellect --- Psychology --- Thought and thinking --- Comprehension --- Executive functions (Neuropsychology) --- Mnemonics --- Perseveration (Psychology) --- Reproduction (Psychology) --- Impairment, Memory --- Memory, Disorders of --- Memory impairment --- Paramnesia --- Cognition disorders --- 5-HT (Neurotransmitter) --- Hydroxytryptamine --- Neurotransmitters --- Tryptamine

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Identification of Neural Markers Accompanying Memory is a fresh and novel volume of memory study, providing up-to-date and comprehensive information for both students and researchers focused on the identification of neural markers accompanying memory. Contributions by experts in specific areas of memory study provide background on and definitions of memory, memory alterations, and the brain areas involved in memory and its related processes, such as consolidation, retrieval, forgetting, amnesia, and antiamnesiac effects. With coverage of the principal neurotransmitters related to memory, brain disorders presenting memory alterations, and available treatments-and with discussion of neural markers as new targets for the treatment of memory alterations-Identification of Neural Markers Accompanying Memory is a necessary and timely work for researchers in this growing field. Discusses the alterations of memory in diverse diseasesIncludes coverage from a basic introduction of memory investigationReviews brain areas and neurotransmitters involved in memoryDiscusses behavioral models of memoryContains novel insights into the complexity of signaling and memoryIncludes the neuropharmacological and neurobiological bases of memory.

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The study of 5-hydroxytryptamine (5-HT) systems has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Increasing evidence suggests that 5-HT pathways, reuptake site/transporter complex and 5-HT receptors represent a strategic distribution for learning and memory. A key question still remaining is whether 5-HT markers (e.g., receptors) are directly or indirectly contributing to the physiological and pharmacological basis of memory and its pathogenesis or, rather, if they represent protective or adaptable mechanisms. Certainly, Alzheimer´s disease (AD) is a very complex neuropsychiatric disorder, where memory becomes progressively dysfunctional resulting in amnesia and dementia, whereas forgetting is a physiological phenomenon occurring all the time as adaptive mechanism. As dysfunctional memory occurs in several neuropsychiatric disorders, including schizophrenia, stroke, post-traumatic stress disorder. Hence, the aim of this call is collect recent and important findings related to information about serotonin and memory or 5-HT and learning or 5-HT and memory or serotonin and learning.

Serotonin. --- Serotonin --- Memory. --- Memory disorders. --- Neuropharmacology. --- Neurosciences. --- Receptors. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Neurotropic drugs --- Neurosciences --- Pharmacology --- Impairment, Memory --- Memory, Disorders of --- Memory impairment --- Paramnesia --- Cognition disorders --- Retention (Psychology) --- Intellect --- Psychology --- Thought and thinking --- Comprehension --- Executive functions (Neuropsychology) --- Mnemonics --- Perseveration (Psychology) --- Reproduction (Psychology) --- 5-HT (Neurotransmitter) --- Hydroxytryptamine --- Neurotransmitters --- Tryptamine --- Drug effects --- Effect of drugs on --- Learning --- 5-Hydroxytryptamine --- forgetting --- Memory --- dysfunctional memory --- neuropsychiatric disorders --- Amnesia --- neural markers --- 5-HT receptors --- 5-HT markers

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Pharmacology --- drugs --- Behavior --- Memory tasks --- pre-clinical --- clinical --- Humans --- Animals