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How do we know what role a particular gene has ? How do some genes control the expression of others ? How do genes interact to form gene networks ? With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the interactions of genes during suppression, synthetic enhancement, and epistasis follows, which is then expanded into a consideration of genetic networks and personal genomics.Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight.We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.
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How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks? This text explores these fascinating questions, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the genetic structure of natural populations follows, before the interaction of genes during suppression and epistasis, how we study gene networks, and personalized genomics are considered. Drawing on the latest experimental tools, including microarrays, RNAi screens, and bioinformatics approaches, this book provides a state-of-the-art review of the field in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader to the forefront of contemporary research with exceptional clarity.
Genetics --- Eukaryotic cells --- Genes --- Genomes --- Genetic Techniques --- Eukaryotic Cells --- Genomics --- Gene Expression Regulation --- Models, Genetic
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Eukaryotic cells --- Genetics --- Eukaryotic Cells --- Gene Expression Regulation --- Genomics --- Models, Genetic --- Research --- Methodology --- physiology
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Recent advances that allow scientists to quickly and accurately sequence a genome have revolutionized our view of the structure and function of genes as well as our understanding of evolution. A new era of genetics is underway, one that allows us to fully embrace Dobzhansky's famous statement that "Nothing in biology makes sense except in the light of evolution".
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