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Immunology. Immunopathology --- Immunoloy --- Congreses --- Allergy and Immunology. --- Allergy Specialty --- Allergy, Immunology --- Immunology and Allergy --- Immunology, Allergy --- Immunology --- Specialty, Allergy --- Allergy and Immunology
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B-LYMPHOCYTES, physiology --- Cell Transformation, Neoplastic --- Gene Expression Regulation --- Lymphoma, physiopathology --- Oncogenes --- congresses --- Congresses --- congresses. --- Congresses. --- B-Lymphocytes --- Physiology --- B cells --- Tumors
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The papers in this book were presented at the 14th Mechanisms in B-cell Neoplasia meeting that was held in Bethesda, Maryland October 21-23, 1996. In 1995 the organizers decided that the format of the meeting would be changed and that specific topics relevant to B-cell neoplasia would be discussed. This year's topic is on the c-myc oncogene in B-cell neoplasia which has been discussed in virtually every previous meeting. Some of the presentations announced for the first time dramatic advances in our understanding of c-myc and because this subject has become highly complex it was thought that devoting the whole meeting to this theme would be appropriate. The book, therefore, repre sents a review of many aspects of the myc problem but by no means is truly comprehensive. In a recent Medline search there were 8,505 references to myc, fully illustrating the magnitude of the interest and depth of this field. The organizers of the meeting have each contributed review chapters that summarize different aspects of the meeting. We thank the National Cancer Institute for sponsoring this workshop and the staff of Cygnus, Inc. , for their outstanding organizational assistance. The organizers are most grateful to Vickie Rogers for assembling the book and dealing with the edi torialization of the manuscripts. MICHAEL POlTER FRITZ MELCHERS Table of Contents M. POlTER and K. B. MARCU The c-myc Story: Where We've Been, Where We Seem to be Going. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . I F.
Carcinogenesis --- Congresses --- Cancer cells --- B cells --- Tumors --- Myc oncogenes --- Myc proteins --- Immunology. --- Cancer research. --- Internal medicine. --- Cancer Research. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Cancer research --- Immunobiology --- Life sciences --- Serology --- Oncology.
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Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel workshop (held 4th-6th October 1998) that has been recorded and, in part, transcribed is being published as papers and discussions within Current Topics. This volume is the latest of a long series which documents the excitements of ground-breaking discoveries as well as the frustrations of our inability to fully understand the mechanisms leading to B cell neoplasia. The papers at the workshop are presented when possible in the sequence in which they were given. However, to facilitate the organization and reading of the book and to highlight gen eral topics and themes, the papers are organized into five sec tions: I B Cell and Plasma Cell Development II Chemokines and Chemokine Receptors III Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations IV Biology of Lymphomagenesis, B-CLL, Autoimmunity V Myeloma, Plasmacytomas and Related Subjects.
B-Lymphocytes --- Cell Transformation, Neoplastic --- Chemokines --- congresses --- Congresses --- congresses. --- Congresses. --- B cells --- Tumors --- Cancer cells --- Cell transformation --- Immunology. --- Cancer research. --- Internal medicine. --- Cancer Research. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Cancer research --- Immunobiology --- Life sciences --- Serology --- B lymphocytes --- Bone marrow derived cells --- Bursa equivalent cells --- Antigen presenting cells --- Lymphocytes
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B-LYMPHOCYTES --- Leukemia, Lymphocytic, Chronic, B-Cell -- immunology -- Congresses. --- B cells -- Tumors -- Congresses. --- immunology --- immunology. --- Immunology. --- B cells --- Tumors --- Congresses --- Differentiation
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Immune response --- Immunity. --- Immune response.
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B cells --- Lymphocytes --- Cancer cells --- Tumors --- Congresses --- Congresses.
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Peptides --- Immunogenetics. --- Immune response --- Peptides. --- Immune response.
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B-Lymphocytes --- Cell Transformation, Neoplastic --- Gene Expression Regulation --- Physiology --- Congresses --- congresses --- Congresses. --- congresses.
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Chromosome Aberrations --- B-Lymphocytes --- Gene Expression Regulation, Neoplastic --- Metabolism --- Congresses. --- B cells --- Tumors --- Congresses
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