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Chemical structure --- Histology. Cytology --- Molecular biology --- protein-engineering --- cytologie --- histologie --- eiwitten --- moleculaire biologie

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Histology. Cytology --- Molecular biology --- Cell physiology. --- Extracellular matrix. --- Molecular biology. --- Cells --- Extracellular Matrix --- physiology.

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Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Collagen. --- Connective Tissue. --- Connective tissues -- Congresses. --- Extracellular matrix. --- Polysaccharides. --- Extracellular Space --- Metalloendopeptidases --- Membrane Glycoproteins --- Antigens, Surface --- Proteins --- Amino Acids, Peptides, and Proteins --- Cellular Structures --- Endopeptidases --- Glycoproteins --- Membrane Proteins --- Antigens --- Metalloproteases --- Peptide Hydrolases --- Biological Factors --- Cells --- Chemicals and Drugs --- Hydrolases --- Anatomy --- Enzymes --- Enzymes and Coenzymes --- Cell Adhesion Molecules --- Extracellular Matrix --- Matrix Metalloproteinases --- Tissue Inhibitor of Metalloproteinases --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Cytology --- Physiology --- Cement substance (Anatomy) --- Ground substance (Anatomy) --- Ground substance (Histology) --- Intercellular matrix --- Interstitial substance --- Matrix, Extracellular --- Life sciences. --- Molecular biology. --- Biochemistry. --- Proteins. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Biochemistry, general. --- Protein Science. --- Molecular Medicine. --- Connective tissues --- Extracellular space --- Cytology. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Cell biology --- Cellular biology --- Cytologists --- Composition --- Health Workforce --- Proteins . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics

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Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series Biology of Extracellular Matrix  provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment.  Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Chemical structure --- Histology. Cytology --- Molecular biology --- protein-engineering --- cytologie --- histologie --- eiwitten --- moleculaire biologie