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This monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson’s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsuka and Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results.

Subthalamus. --- Subthalamus --- Cytology. --- Development. --- Medicine. --- Neurosciences. --- Biomedicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Corpus subthalamicum --- Brain --- Diencephalon

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This book offers a critical review of the head and neck from an anatomical, physiological and clinical perspective. It begins by providing essential anatomical and physiological information, then discusses historical and current views on specific aspects in subsequent chapters. For example, the anatomy of the skull cap or cranial vault provided in the first chapter is discussed in the context of malformation and identity, as well as the development of the bony skull, in the following chapters. These chapters provide stepping-stones to guide readers through the book. There are new fields of research and technological developments in which Anatomy and Physiology lose track of progress. One of the examples discussed is the automated face recognition. In some respects, e.g. when it comes to cancers and malformations, our understanding of the head and neck – and the resulting therapeutic outcomes – have been extremely disappointing. In others, such as injuries following car accidents, there have been significant advances in our understanding of head and neck dysfunctions and their treatment. Therefore head movements, also during sleep, and head and neck reflexes are discussed. The book makes unequivocal distinctions between correct and incorrect assumptions and provides a critical review of alternative clinical methods for head and neck dysfunctions, such as physiotherapy and lymphatic drainage for cancers. Moreover, it discusses the consequences of various therapeutic measures for physiological and biomechanical conditions, as well as puberty and aging. Lastly, it addresses important biomedical engineering developments for hearing e.g. cochlear implants and for applying vestibular cerebellar effects for vision. .

Human anatomy --- Human physiology --- Neuropathology --- Surgery --- neurologie --- hoofd --- puberteit --- chirurgie --- anatomie --- fysiologie

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(will follow).

Spinal cord. --- Neuroanatomy. --- Central nervous system. --- Nervous system, Central --- Nervous system --- Nerves --- Anatomy --- Neurobiology --- Central nervous system --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences

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This monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson’s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsuka and Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results.

Subthalamus. --- Subthalamus --- Basal ganglia. --- Neural networks (Neurobiology) --- Cytology. --- Biological neural networks --- Nets, Neural (Neurobiology) --- Networks, Neural (Neurobiology) --- Neural nets (Neurobiology) --- Cognitive neuroscience --- Neurobiology --- Neural circuitry --- Ganglia, Basal --- Efferent pathways --- Extrapyramidal tracts --- Telencephalon --- Corpus subthalamicum --- Brain --- Diencephalon --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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Neuropathology --- neurologie