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Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.  In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.

Medicine. --- Pancreas -- Cancer -- Genetic aspects. --- Pancreatic neoplasms -- Genetics. --- Pancreas --- Biochemistry --- Digestive System Neoplasms --- Biology --- Neoplasms by Site --- Biological Science Disciplines --- Natural Science Disciplines --- Neoplasms --- Disciplines and Occupations --- Diseases --- Genetics --- Molecular Biology --- Pancreatic Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Molecular aspects --- Cancer --- Genetic aspects --- Molecular aspects. --- Genetic aspects. --- Cancer genetics --- Cancer research. --- Human genetics. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Human Genetics. --- Cancer genes --- Oncology. --- Cytology. --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Cancer research

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This book provides a comprehensive, state-of-the-art overview of pancreatic cancer. The text presents new data about risk factors and genetic predisposition for pancreatic cancer, highlights current screening strategies and preliminary results, and reviews diagnosis and staging of pancreatic cancer, with a focus on imaging evaluations, laparoscopy, endoscopic ultrasound-guided biopsies, and biomarkers. The book also spotlights emerging paradigms in pancreatic cancer management, such as minimally invasive surgical approaches and emerging radiation approaches, and provides valuable insight into the role of nutrition and early integration of supportive/palliative care for pancreatic cancer patients. Written by experts in the field, Pancreatic Cancer: A Multidisciplinary Approach is an invaluable resource for physicians and researchers with an interest in pancreatic cancer.

Human medicine --- geneeskunde