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This volume gives the reader a comprehensive overview of the fundamental and biological aspects of aging. First, the field is described from a historical perspective. Then, the author analyzes the three fundamental mechanisms of survival: energy utilization, molecular and cellular redundancy, and the organization of information. The genetics of aging is reviewed rejecting some simple-minded interpretations. A bridge is established between the molecular, cellular, and tissue modifications that have been reported in the literature, and the clinical manifestations of the aging syndrome. Special relevance is given to the problem of the supposed association between cancers and aging, giving a new interpretation of that relationship.

612.6 --- Aging --- -Aging --- -Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Voortplanting. Groei. Ontwikkeling --- Molecular aspects --- Physiological aspects --- Physiological effect --- Molecular aspects. --- Physiological aspects. --- -Voortplanting. Groei. Ontwikkeling --- Molecular aging --- Molecular biology --- Geriatrics. --- Developmental biology. --- Cancer research. --- Geriatrics/Gerontology. --- Developmental Biology. --- Cancer Research. --- Cancer research --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Medicine --- Older people --- Diseases --- Health and hygiene

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Antioncogenes. --- Cancer cells --- Cells --- Growth factors. --- Interferon. --- Oncogenes. --- Growth --- Regulation. --- Antioncogenes --- Growth factors --- Interferon

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General embryology. Developmental biology --- Histology. Cytology --- Molecular biology --- Human biochemistry --- Oncology. Neoplasms --- Pathological biochemistry --- biochemie --- oncologie --- cytologie --- embryologie (geneeskunde) --- histologie --- moleculaire biologie

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Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.

embryologie (geneeskunde) --- histologie --- Histology. Cytology --- Oncology. Neoplasms --- General embryology. Developmental biology --- oncologie --- cytologie --- Cell division --- Cell differentiation --- Genetic recombination --- Symmetry (Biology) --- Biodiversity --- Cellules --- Recombinaison génétique --- Molecular aspects --- Genetic aspects --- Division --- Life Sciences --- Biology --- Molecular biology --- Biologie moléculaire --- Biologie moléculaire --- MDBIOCHE --- Cell differentiation. --- Cell division. --- Developmental biology. --- Cytology. --- Oncology. --- Developmental Biology. --- Cell Biology. --- Cancer Research. --- Tumors --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Cell biology. --- Cancer research. --- Cancer research