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This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.

Technology: general issues --- lactate biosensor --- enzyme electrode --- off-line monitoring --- screen-printing --- at-line measurement --- in-line monitoring --- cell viability --- prediction --- chromatogram fingerprinting --- filamentous fungi --- Penicillium chrysogenum --- Trichoderma reesei Rut-C30 --- HPLC-SEC --- AAV-adeno-associated virus --- insect cell-baculovirus --- cell culture monitoring --- digital holographic microscopy --- process analytical technology --- pH --- pCO2 --- off-gas measurement --- carbon dioxide --- cell culture --- reference --- CHO --- automated sampling --- bioprocess --- amino acids --- vitamins --- Raman spectroscopy --- mammalian cell culture --- high-throughput --- scale-down technologies --- cation exchange chromatography --- monitoring --- PAT --- IgG titer --- real-time --- on-line --- nanoplasmonic --- AAV—adeno-associated virus --- gene therapy --- dielectric spectroscopy --- n/a

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Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions at a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or bioreactors for the production of biologics. This book highlights these issues with much focus on new engineering design approached. Initial chapters cover conceptual design of microbioreactors and organ-on-chips, and the role of microbioreactors in tissue engineering for the clinical and for therapeutic targets. Two chapters are dedicated to microbioreactors for implementing tumour models. Other chapters discuss three-dimensional models for hepatic and cardiac cells for toxicity testing and drug evaluation. Finally, the design of organ chips for cartilage scaffolds and integration of sensors are covered in separate chapters. We believe the book have substantial value for researchers active in bioreactor engineering, drug development and cell physiology as well as readers interested in the these topics.

Bioreactors.

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This book is devoted to new developments in measurement technologies for upstream and downstream bioprocessing. The recent advances in biotechnology and bioprocessing have generated a number of new biological products that require more qualified analytical technologies for diverse process analytical needs. These includes especially fast and sensitive measurement technology that, early in the process train, can inform on critical process parameters related to process economy and product quality and that can facilitate ambitions of designing efficient integrated end-to-end bioprocesses. This book covers these topics as well as analytical monitoring methods based either on real-time or in-line sensor technology, on simple and compact bioanalytical devices, or on the use of advanced data prediction methods.

Technology: general issues --- lactate biosensor --- enzyme electrode --- off-line monitoring --- screen-printing --- at-line measurement --- in-line monitoring --- cell viability --- prediction --- chromatogram fingerprinting --- filamentous fungi --- Penicillium chrysogenum --- Trichoderma reesei Rut-C30 --- HPLC-SEC --- AAV-adeno-associated virus --- insect cell-baculovirus --- cell culture monitoring --- digital holographic microscopy --- process analytical technology --- pH --- pCO2 --- off-gas measurement --- carbon dioxide --- cell culture --- reference --- CHO --- automated sampling --- bioprocess --- amino acids --- vitamins --- Raman spectroscopy --- mammalian cell culture --- high-throughput --- scale-down technologies --- cation exchange chromatography --- monitoring --- PAT --- IgG titer --- real-time --- on-line --- nanoplasmonic --- AAV-adeno-associated virus --- gene therapy --- dielectric spectroscopy --- lactate biosensor --- enzyme electrode --- off-line monitoring --- screen-printing --- at-line measurement --- in-line monitoring --- cell viability --- prediction --- chromatogram fingerprinting --- filamentous fungi --- Penicillium chrysogenum --- Trichoderma reesei Rut-C30 --- HPLC-SEC --- AAV-adeno-associated virus --- insect cell-baculovirus --- cell culture monitoring --- digital holographic microscopy --- process analytical technology --- pH --- pCO2 --- off-gas measurement --- carbon dioxide --- cell culture --- reference --- CHO --- automated sampling --- bioprocess --- amino acids --- vitamins --- Raman spectroscopy --- mammalian cell culture --- high-throughput --- scale-down technologies --- cation exchange chromatography --- monitoring --- PAT --- IgG titer --- real-time --- on-line --- nanoplasmonic --- AAV-adeno-associated virus --- gene therapy --- dielectric spectroscopy

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Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy, by Bernhard Sonnleitner Automatic Control of Bioprocesses, by Marc Stanke, Bernd Hitzmann An Advanced Monitoring Platform for Rational Design of Recombinant Processes, by G. Striedner, K. Bayer Modelling Approaches for Bio-Manufacturing Operations, by Sunil Chhatre Extreme Scale-Down Approaches for Rapid Chromatography Column Design and Scale-Up During Bioprocess Development, by Sunil Chhatre Applying Mechanistic Models in Bioprocess Development, by Rita Lencastre Fernandes, Vijaya Krishna Bodla, Magnus Carlquist, Anna-Lena Heins, Anna Eliasson Lantz, Gürkan Sin and Krist V. Gernaey Multivariate Data Analysis for Advancing the Interpretation of Bioprocess Measurement and Monitoring Data, by Jarka Glassey Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks, by Inês A. Isidro, Ana R. Ferreira, João J. Clemente, António E. Cunha, João M. L. Dias, Rui Oliveira Knowledge Management and Process Monitoring of Pharmaceutical Processes in the Quality by Design Paradigm, by Anurag S Rathore, Anshuman Bansal, Jaspinder Hans The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses, by Ian Marison, Siobhán Hennessy, Róisín Foley, Moira Schuler, Senthilkumar Sivaprakasam, Brian Freeland.

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