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Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. The known pharmacokinetics of the relevant constituents and the biopharmaceutical quality of commercially available Hypericum preparations are also discussed.

Hypericum perforatum --- Affective disorders --- Therapeutic use. --- Treatment. --- Disorders, Affective --- Mood disorders --- Psychology, Pathological --- Common Saint Johnswort --- Klamath weed --- Perforate Saint Johnswort --- Saint Johns-wort, Common --- Saint Johnswort, Common --- St. Johnswort, Common --- Tipton's weed --- Hypericum --- Toxicology. --- Neurosciences. --- Neurology. --- Psychiatry. --- Psychotherapy. --- Biochemistry. --- Pharmacology/Toxicology. --- Plant Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Psychagogy --- Therapy (Psychotherapy) --- Mental illness --- Clinical sociology --- Mental health counseling --- Medicine and psychology --- Mental health --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Composition --- Treatment --- Diseases --- Toxicology --- Pharmacology. --- Neurology . --- Psychotherapy   . --- Plant biochemistry. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. The known pharmacokinetics of the relevant constituents and the biopharmaceutical quality of commercially available Hypericum preparations are also discussed.

Pharmacology. Therapy --- Psychiatry --- Neuropathology --- Biochemical engineering --- neurologie --- psychiatrie --- farmacologie --- biochemie --- psychotherapie --- hersenen --- toxicologie --- planten

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

neurodegenerative diseases --- aging --- Parkinson's disease --- Alzheimer's disease --- neurodegeneration --- β-amyloid --- Aβ

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