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JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

JAK-STAT pathway. --- Cytokines. --- Molecular biology. --- Oncology. --- Signal transduction. --- Pathology, Molecular --- Cellular signal transduction --- Proteins --- Cell Physiological Processes --- Biochemical Processes --- Intracellular Signaling Peptides and Proteins --- Adaptor Proteins, Signal Transducing --- Biological Science Disciplines --- Transcription Factors --- Receptors, Immunologic --- Protein-Tyrosine Kinases --- Receptors, Cell Surface --- Cell Physiological Phenomena --- Protein Kinases --- Chemical Processes --- Biochemical Phenomena --- Natural Science Disciplines --- Carrier Proteins --- Chemical Phenomena --- Amino Acids, Peptides, and Proteins --- Phosphotransferases (Alcohol Group Acceptor) --- Disciplines and Occupations --- Phenomena and Processes --- Peptides --- Membrane Proteins --- Chemicals and Drugs --- Phosphotransferases --- Transferases --- Enzymes --- Enzymes and Coenzymes --- STAT Transcription Factors --- Physiology --- Receptors, Cytokine --- Signal Transduction --- Janus Kinases --- Medicine --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Pathology --- Cytology --- Animal Biochemistry --- Cellular signal transduction. --- Molecular biochemistry --- Molecular biophysics --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Life sciences. --- Cancer research. --- Medical genetics. --- Immunology. --- Hematology. --- Cell biology. --- Stem cells. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Cancer Research. --- Gene Function. --- Cellular immunity --- Immune response --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Regulation --- Cytology. --- Haematology --- Internal medicine --- Blood --- Immunobiology --- Life sciences --- Serology --- Tumors --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Genetic disorders --- Genetic aspects --- Cancer research

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JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

Histology. Cytology --- Immunology. Immunopathology --- Oncology. Neoplasms --- Pathological haematology --- immunologie --- stamcellen --- oncologie --- hematologie --- cytologie --- stamceltransplantatie --- histologie

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Purines --- Uric acid --- Metabolism, Inborn errors of --- Gout --- Purine-pyrimidine metabolism, Inborn --- Carbohydrates --- Lipids --- Metabolism --- Congresses --- Enzymology --- errors --- Congresses. --- Maladies héréditaires métaboliques --- Congrès --- Errors --- Maladies héréditaires métaboliques --- Congrès

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