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This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model. Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer. The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.

Cancer --- Treatment --- Technological innovations. --- Chemistry. --- Cancer research. --- Spectroscopy. --- Medicinal chemistry. --- Nanochemistry. --- Biomedical engineering. --- Biomaterials. --- Cancer Research. --- Spectroscopy/Spectrometry. --- Biomedical Engineering. --- Medicinal Chemistry. --- Oncology. --- Biochemistry. --- Biomedical Engineering and Bioengineering. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Analysis, Spectrum --- Spectra --- Spectrochemical analysis --- Spectrochemistry --- Spectroscopy --- Chemistry, Analytic --- Interferometry --- Optics --- Radiation --- Wave-motion, Theory of --- Absorption spectra --- Light --- Spectroscope --- Biocompatible materials --- Biomaterials --- Medical materials --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Tumors --- Nanoscale chemistry --- Nanoscience --- Composition --- Qualitative --- Spectrometry --- Analytical chemistry --- Bioartificial materials --- Hemocompatible materials --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Cancer research --- Biomaterials (Biomedical materials)

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Aan de hand van tekeningen in pictogramstijl toont dit boekje telkens twee benaderingen van een onderwerp: een 'typisch' mannelijke en een 'typisch' vrouwelijke kijk op relaties, winkelen, de weg vinden... Een leuke manier om genderstereotypen en rolpatronen aan bod te laten komen.

Symbolen --- Culturele antropologie --- Symbool --- Sociology of the family. Sociology of sexuality --- Didactics of social education --- Secondary education

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This project encompasses various aspects of bridge health-monitoring, maintenance and safety. It specifically deals with: bridge health-monitoring; bridge repair and rehabilitation issues; bridge-related safety and other implications. The objective of the project is to introduce recent research results into the fields of bridge health monitoring, bridge maintenance and safety. It should be required reading not only for civil and mechanical engineers, but also municipal functionaries. Review from Book News Inc.: Intended for engineering graduate students and infrastructure maintenance managers,

Bridges --- Maintenance and repair. --- Testing. --- Repairing

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The amount of deteriorating bridges is increasing gradually, and the costs of maintenance, repair and rehabilitation of these bridges often far exceed available budgets. To alleviate this issue, the bridge engineering profession continues to take positive steps towards developing more comprehensive bridge monitoring and management systems. This collection of invited papers encompasses some aspects of bridge health monitoring, maintenance and safety. Specifically, it deals with: bridge health monitoring; bridge repair and rehabilitation issues; bridge related safety and other implications. Edit

Bridges --- Maintenance and repair. --- Testing. --- Repairing

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Dit mooi vormgegeven drietalige boekje geeft de verschillen tussen de Oosterse en Westerse culturele denkkaders grafisch weer. De kleuren rood en blauw en de pictogrammen symbolizeren de verschillen in communicatiestijlen en culturele waarden in China en Duitsland. Ze zijn gebaseerd op de ervaringen van de Chinees-Duitse auteur.

Sociology of culture --- Didactics of social education --- Germany --- China