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Handbook outline the use of metabonomics in the safety assessment of new chemical entities.
Biochemical toxicology. --- Biological Markers --- Magnetic Resonance Spectroscopy --- Nuclear magnetic resonance spectroscopy. --- Toxicology --- analysis. --- methods. --- methods.
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Metabolism --- Disorders --- Genetic aspects. --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology
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Molecular biology operates at three levels - genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These ""omics"" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields
Molecular biology --- Biochemistry --- Gene expression --- Metabolism --- Biomolecules --- Technique --- Metabolism. --- Molecular genetics. --- Biomolecules. --- Laboratorio de Análisis Metabolómico (71102203) |x Bibliografía recomendada --- Biological molecules --- Molecules --- Genetics --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Physiology --- Genes --- Genetic regulation --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Systems biology --- Expression --- Composition --- Molecular biology - Technique - Handbooks, manuals, etc --- Biochemistry - Technique - Handbooks, manuals, etc --- Gene expression - Technique - Handbooks, manuals, etc
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Human genetics --- Metabolism --- Disorders --- Genetic aspects. --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology
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Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.
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The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics.
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Molecular biology operates at three levels genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies * aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification * covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.
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Spectrometers --- Spectroscopy --- Spectrometers --- Spectroscopy
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Spectrometers --- Spectroscopy --- Spectrometers --- Spectroscopy
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