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Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and
Molecular pharmacology --- Molecular biology --- Pharmacologie moléculaire --- Biologie moléculaire --- Quadruplex nucleic acids --- Nucleic Acid Conformation --- DNA --- Genetic Structures --- Nucleic Acids --- Molecular Conformation --- Genetic Phenomena --- Nucleic Acids, Nucleotides, and Nucleosides --- Molecular Structure --- Chemicals and Drugs --- Biochemical Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Pharmacologie moléculaire --- Biologie moléculaire
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DNA-drug interactions --- DNA-binding proteins --- Gene targeting --- Drug targeting --- Chemotherapy --- DNA-Binding Proteins. --- Dna-drug interactions
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PROTEINS --- PROTEIN FOLDING --- DENATURATION --- PROTEINS --- PROTEIN FOLDING --- DENATURATION
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While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples.
Protein folding. --- RNA. --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose --- Folding of proteins --- Proteins --- Folding --- Conformation --- Biophysics. --- Experimental Techniques. --- Prediction Methods.
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