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Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials on therapeutic compounds are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in research and treatment in this exciting field.

Angiogenesis Inhibitors. --- Neoplasms -- drug therapy. --- Neovascularization inhibitors. --- Neovascularization, Pathologic -- drug therapy. --- Neovascularization inhibitors --- Neoplasms --- Angiogenesis Inhibitors --- Drug Therapy --- Neovascularization, Pathologic --- Therapeutics --- Diseases --- Angiogenesis Modulating Agents --- Metaplasia --- Antineoplastic Agents --- Growth Inhibitors --- Therapeutic Uses --- Growth Substances --- Pathologic Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacologic Actions --- Physiological Effects of Drugs --- Pathological Conditions, Signs and Symptoms --- Chemical Actions and Uses --- Chemicals and Drugs --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Therapeutic use. --- Chemotherapy. --- Angiogenesis inhibitors --- Tumor angiogenesis inhibitors --- Medicine. --- Cancer research. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Tumors --- Haematology --- Internal medicine --- Blood --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents --- Treatment