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This book constitutes the refereed proceedings of the 11th International Symposium on Bioinformatics Research and Applications, ISBRA 2015, held in Norfolk, VA, USA, in June 2015. The 34 revised full papers and 14 two-page papers included in this volume were carefully reviewed and selected from 98 submissions. The papers cover a wide range of topics in bioinformatics and computational biology and their applications.

Computer Science. --- Computational Biology/Bioinformatics. --- Data Mining and Knowledge Discovery. --- Pattern Recognition. --- Mathematical and Computational Biology. --- Computer science. --- Data mining. --- Optical pattern recognition. --- Bioinformatics. --- Informatique --- Exploration de données (Informatique) --- Reconnaissance optique des formes (Informatique) --- Bio-informatique --- Biology --- Health & Biological Sciences --- Biology - General --- Pattern recognition. --- Biomathematics. --- Mathematics --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Design perception --- Pattern recognition --- Form perception --- Perception --- Figure-ground perception --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Informatics --- Science --- Data processing --- Optical data processing --- Pattern perception --- Perceptrons --- Visual discrimination