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With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.
Artificial intelligence. --- Computational biology. --- Computational intelligence. --- Computer Simulation. --- Neural Networks (Computer). --- RNA --- Three-dimensional imaging --- Sequence Analysis --- Natural Science Disciplines --- Nucleic Acids --- Models, Theoretical --- Disciplines and Occupations --- Genetic Techniques --- Nucleic Acids, Nucleotides, and Nucleosides --- Investigative Techniques --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Sequence Analysis, RNA --- Chemistry --- Models, Molecular --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Animal Biochemistry --- Biochemistry --- Computer simulation --- Three-dimensional imaging. --- Computer simulation. --- 3-D imaging --- 3D imaging --- Three-dimensional imaging systems --- Three-dimensional imaging techniques --- Three-dimensional visualization --- Visualization, Three-dimensional --- Ribonucleic acid --- Ribose nucleic acid --- Life sciences. --- Biochemistry. --- Nucleic acids. --- Life Sciences. --- Nucleic Acid Chemistry. --- Biochemistry, general. --- Imaging systems --- Nucleic acids --- Ribose --- Molecular Biology --- DNA --- Molecular biology --- ADN --- Biologie moléculaire --- Acides nucléiques --- Periodicals. --- periodicals. --- Periodicals --- Périodiques --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Polynucleotides --- Biomolecules --- Composition
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Nucleic acids --- Nucleic acids --- Structure --- Structure --- Computer simulation
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While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples.
Protein folding. --- RNA. --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose --- Folding of proteins --- Proteins --- Folding --- Conformation --- Biophysics. --- Experimental Techniques. --- Prediction Methods.
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