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Foreword written by Samuel A. Wells, Jr., MD Professor of Surgery Duke University Medical Center, Durham, NC According to the American Cancer Society, about 1 million persons in the United States will be diagnosed with solid cancer every year. About 50% of them will be potentially cured by surgery. The other half of the population may develop metastatic cancer. To date, there is no systemic treatment available to cure metastatic cancer. Therefore, cancer clinical trials are critical to evaluate reliable treatment modalities against metastatic cancer. Likewise, adjuvant trials are needed to prevent high risk patients from developing recurrence following definitive surgical resection of their cancer. Only about 3-5% of the adult cancer patients are enrolled in clinical trials. When the pediatric cancer clinical trial groups were able to accrue over 40 percent of eligible patients to their clinical trials, significant impact was made on the survival of these pediatric cancer patients. However, multiple barriers exist to block adult cancer patients from entering into clinical protocols. The ever-changing regulations for clinical trials and the ethical dilemma of treating cancer patients as subjects have made it ever so difficult for the principal investigators to conduct clinical research, especially when they are often ill-informed of the complex nature of the regulations and over-worked. Therefore, cancer clinical trials are at a critical junction. The objective of this book is to bring the issues of cancer clinical trials into focus so that proactive strategies may be developed to make such trials more user-friendly. Ultimately, the cancer patients will be benefited. "Clinical trials remain the most important vehicle for improving the care of cancer patients. This text presents the fundamental components and challenges involving clinical investigations. Leading experts discuss the critical issues covering the spectrum of important topics from planning to application." Steven T. Rosen, M.D. Series Editor.

Cancer --- Clinical trials --- Research --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Oncology  .

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In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.

Lymphatic Metastasis -- Congresses. --- Metastasis. --- Oncology --- Medicine --- Health & Biological Sciences --- Metastasis --- Lymphangiogenesis --- Congresses --- Neovascularization, Pathologic --- Neoplasm Invasiveness --- Antineoplastic Combined Chemotherapy Protocols --- Lymphatic Metastasis --- Organogenesis --- Neoplasm Metastasis --- Publication Formats --- Antineoplastic Protocols --- Neoplastic Processes --- Metaplasia --- Drug Therapy, Combination --- Pathologic Processes --- Embryonic and Fetal Development --- Clinical Protocols --- Publication Characteristics --- Neoplasms --- Drug Therapy --- Morphogenesis --- Therapeutics --- Pathological Conditions, Signs and Symptoms --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Growth and Development --- Physiological Processes --- Physiological Phenomena --- Phenomena and Processes --- Lymphatic metastasis. --- Oncology. --- Medicine. --- Radiotherapy. --- Pathology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Tumors --- Lymphatics --- Cancer --- Oncology  . --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Radiological services --- Excision --- Treatment --- Cancer metastasis --- Lymphovascular system

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Oncology. Neoplasms --- oncologie

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Radiotherapy. Isotope therapy --- Oncology. Neoplasms --- Pathology --- pathologie --- farmacologie --- radiotherapie --- oncologie --- metastase

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