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Book
Microcredit Guarantee Funds in the Mediterranean : A Comparative Analysis
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ISBN: 1349497576 1137452994 Year: 2014 Publisher: London : Palgrave Macmillan UK : Imprint: Palgrave Macmillan,

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Abstract

This book offers a comprehensive comparative analysis of the microcredit guarantee funds adopted in three South European countries and in three North African countries. It focuses on three keys areas: analysis of the regulatory framework, mapping of microcredit institutions and analysis of the main features of guarantee funds.


Article
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective.
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Year: 1999

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Article
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective.
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Year: 1999

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The mammalian brain has a high degree of plasticity, with dentate granule cell neurogenesis(1) and glial(2,3) proliferation stimulated by an enriched environment combining both complex inanimate and social stimulation. Moreover, rodents exposed to an enriched environment both before and after a cerebral insult show improved cognitive performance(1,4). One of the most robust associations of environmental enrichment is improved learning and memory in the Morris water maze, a spatial task that mainly involves the hippocampus(5). Furthermore, clinical evidence showing an association between higher educational attainment and reduced risk of Alzheimer(6) and Parkinson-related dementia(7) indicates that a stimulating environment has positive effects on cerebral health that may provide some resilience to cerebral insults. Here we show that in addition to its effects on neurogenesis, an enriched environment reduces spontaneous apoptotic cell death in the rat hippocampus by 45%. Moreover, these environmental conditions protect against kainate-induced seizures and excitotoxic injury. The enriched environment induces expression of glial-derived neurotrophic factor and brain-derived neurotrophic factor and increases phosphorylation of the transcription factor cyclic-AMP response element binding protein, indicating that the; influence of the environment on spontaneous apoptosis and cerebral resistance to insults may be mediated through transcription factor activation and induction of growth factor expression

Principles of Molecular Neurosurgery
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ISBN: 1280513527 1423714083 3318011142 3805577842 9786610513529 Year: 2005 Publisher: Basel S. Karger

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