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This book offers a comprehensive overview of the microbiological fundamentals and biotechnological applications of methanotrophs: aerobic proteobacteria that can utilize methane as their sole carbon and energy source. It highlights methanotrophs’ pivotal role in the global carbon cycle, in which they remove methane generated geothermally and by methanogens. Readers will learn how methanotrophs have been employed as biocatalysts for mitigating methane gas and remediating halogenated hydrocarbons in soil and underground water. Recently, methane has also attracted considerable attention as a potential next-generation carbon feedstock for industrial biotechnology, because of its abundance and low price. Methanotrophs can be used as biocatalysts for the production of fuels, chemicals and biomaterials including methanobactin from methane under environmentally benign production conditions. Sharing these and other cutting-edge insights, the book offers a fascinating read for all scientists and students of microbiology and biotechnology.
Methanotrophs. --- Bacteriology. --- Microbiology. --- Metabolism. --- Biochemistry. --- Applied Microbiology. --- Metabolomics. --- Plant Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Microbial biology --- Microorganisms --- Microbiology --- Composition --- Plant biochemistry. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Botany --- Phytochemicals --- Plant biochemical genetics
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The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in the chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways. The catalytic efficiency and chemo-, regio-, and stereo-selectivity of enzymes can be enhanced and modulated using protein engineering. Metabolic engineering seeks to enhance cellular biosynthetic productivity of target metabolites via controlling and redesigning metabolic pathways using multi-omics analysis, genome-scale modeling, metabolic flux control, and reconstruction of novel pathways. The aim of this book is to cover the recent advances in biocatalysis and metabolic engineering for biomanufacturing of biofuels, chemicals, biomaterials, and pharmaceuticals. Reviews and original research articles on the development of new strategies to improve the catalytic efficiency of enzymes, biosynthetic capability of cell factories, and their applications in production of various bioproducts and chemicals are included.
n/a --- fluorescein diacetate --- Methylosinus sporium strain 5 --- soluble methane monooxygenase --- tunable expression system --- FTIR spectroscopy --- mevalonate kinase 1 --- poly(ethylene glycol) --- tetraethylene glycol --- review --- mevalonate (MVA) --- biofilm --- 5-hydroxymethylfurfural --- polymer functionalization --- microbial production --- microbial cell factory --- bio-hydrogen --- redox enzymes --- specific recognition --- fed-batch fermentation --- monoterpene --- Vitreoscilla --- Pvgb --- bioreactor --- 3-hydroxypropionic acid --- cascade reactions --- synthetic biology --- aerobic methane bioconversion --- starch hydrolysis --- CYP153A --- MEP pathway --- cross-linked enzyme aggregate --- interfacial activation --- expression vectors --- Combi-CLEAs --- polyethyleneimine --- bovine serum albumin --- polyurethane foam --- 12-hydroxydodecanoic acid --- MEV pathway --- amyloglucosidase --- total enzymatic activity --- Nylon 12 --- biocatalytic reaction --- Myceliophthora --- whole-cell biotransformation --- magnetic nanoparticles --- lipase immobilization --- Methanosarcina mazei --- biocatalysis --- acetate --- vgb --- C–H activation --- artificial self-sufficient P450 --- whole cell --- bioplastics --- Corynebacterium glutamicum --- chemicals addition --- enzyme modulation --- Eversa --- enzyme stabilization --- biocatalysts --- prokaryotic microbial factory --- synthetic metabolic pathways --- mannose --- immobilization --- (?)-?-bisabolol --- hydrogenase --- O2 activation --- string film reactor --- fatty acid synthesis --- ?-aminododecanoic acid --- transesterification --- mass transfer performance --- dodecanoic acid --- metabolic engineering --- glyoxal oxidase --- small molecules --- Candida antarctica Lipase B --- C-H activation
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