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This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
Chemokines --- Virus diseases --- Pathophysiology. --- Pathogenesis. --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Cytokines --- Inflammation --- Peptides --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Mediators --- Microbiology. --- Medical Microbiology. --- Microbial biology --- Biology --- Microorganisms --- Medical microbiology.
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This volume serves as a succinct and well-organized reference volume focused on inflammatory CNS disease to a wide audience. The text is comprised of four sections revolving around current areas of interest in the fields of neuroimmunology, virology, pharmacology and disease. Sections of this text focus on a specific category of diseases as well as the pharmacological, virological, and immunological effects of and on the disease. Although many have covered this topic, few have provided a volume as concise and efficient. Each disease is broken down on a variety of scientific levels without getting into the history of the disease. This approach provides a succinct overview of a specific subject encompassing interrelated topics pertaining to neurology, immunology and disease. The information provided in Central Nervous System Diseases and Inflammation will be useful for researchers, clinicians, as well as a valuable resource for students interested in the fascinating arena of neuroinflammation.
Central nervous system --- Inflammation. --- Neuroimmunology. --- Diseases. --- Diseases --- Immunological aspects. --- Neuroimmunomodulation --- Immunology --- Neurosciences --- Inflammatory process --- Pathology --- Anti-inflammatory agents --- Nervous system, Central --- Nervous system --- Immunology. --- Neurosciences. --- Medical virology. --- Microbiology. --- Toxicology. --- Virology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Microbial biology --- Biology --- Microorganisms --- Medical microbiology --- Virology --- Virus diseases --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Toxicology --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Microbiology --- Physiological effect
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