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There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, s

Drug design. --- Drugs -- Design. --- Drugs. --- Biochemical Processes --- Investigative Techniques --- Chemistry, Pharmaceutical --- Metabolism --- Laboratory Chemicals --- Pharmacology --- Chemical Processes --- Specialty Uses of Chemicals --- Metabolic Phenomena --- Chemistry --- Biochemical Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Chemical Phenomena --- Chemical Actions and Uses --- Biological Science Disciplines --- Natural Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Drug Discovery --- Protein Binding --- Drug Design --- Small Molecule Libraries --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Drugs --- Design. --- Drug development. --- Drug design --- Pharmaceutical design --- Development of drugs --- New drug development --- Development --- Drug development --- Pharmacy

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ADN polymérases --- ADN viral --- ARN polymérases --- Enzymes virales --- Polymerases --- Viruses