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Ocular pharmacology. --- Ophthalmic drugs. --- Eye --- Ophthalmopharmacology --- Pharmacology --- Ophthalmic drugs --- Materia medica, Ophthalmological --- Ophthalmic agents --- Drugs --- Therapeutics, Ophthalmological --- Ocular pharmacology --- Drug effects --- Effect of drugs on --- Farmacologia ocular --- Efecte dels medicaments sobre l'ull --- Efectes dels medicaments sobre l'ull --- Farmacologia oftalmològica --- Oftalmofarmacologia --- Farmacologia --- Col·liris
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This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use. Beginning with a perspective on anatomy and physiology of the eye, the book provides a critical appraisal of principles that underlie ocular drug product development. The coverage encompasses topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products. Critical elements such as pharmacokinetics, influence of formulation technologies and ingredients, as well as impact of disease conditions on products development are addressed. Products intended for both the front and the back of the eye are discussed with an eye towards future advances.
Pharmacology. Therapy --- Ophthalmology --- farmacologie --- oftalmologie
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Nanoparticles, products of nanotechnology, are of increasing interest to the pharmaceutical community. They can increase drug solubility, enhance bioavailability, allow tissue targeting, offer decreased side-effects, and improve therapeutic efficacy. Presenting the most pertinent and practical issues in the manufacturing and biological application of nanoparticles, this source presents state-of-the-art scientific contributions by seasoned authorities in the field.
Drug Delivery Systems. --- Nanostructures. --- Drug Administration Routes. --- Nanotechnology --- Nanoparticles. --- Drug delivery systems. --- Nanoparticules --- Médicaments --- methods. --- Administration --- Dispositifs --- Médicaments --- Nanoparticules. --- Drugs --- Methods. --- Administration. --- Nanotechnology - methods.
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Pharmacology. Therapy --- Ophthalmology --- farmacologie --- toxicologie --- oftalmologie
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This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Clinical endpoints and regulatory path to drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Uday B. Kompella, Ph.D., Professor of Pharmaceutical Sciences & Ophthalmology, University of Colorado, developed functionalized nanoparticles, nanoporous microparticles, microparticles, injectable implants, dendrimers, liposomes, and in situ forming gels for the eye. He is a Fellow of the American Association of Pharmaceutical Scientists (2005) and the Association for Research in Vision and Ophthalmology (2010). He received Distinguished Scientist (2006) Award from the University of Nebraska. Henry F. Edelhauser, Ph.D., Professor of Ophthalmology, Emory University, made pioneering contributions towards transcorneal, transscleral, and suprachoroidal drug delivery to the eye. He is a recipient of the Castroviejo Medal and the Alcon Research Award (1999), American Academy of Ophthalmology Senior Achievement Award (2000), and the Procter Medal (2005) for his outstanding ophthalmic translational research. He served as the president of the Association for Research in Vision and Ophthalmology (1990-91).
Pharmacology. Therapy --- Ophthalmology --- farmacologie --- toxicologie --- oftalmologie
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Pharmacology. Therapy --- Ophthalmology --- farmacologie --- oftalmologie --- Ocular pharmacology. --- Ophthalmic drugs. --- Eye --- Ophthalmopharmacology --- Pharmacology --- Ophthalmic drugs --- Materia medica, Ophthalmological --- Ophthalmic agents --- Drugs --- Therapeutics, Ophthalmological --- Ocular pharmacology --- Drug effects --- Effect of drugs on
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This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Clinical endpoints and regulatory path to drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Uday B. Kompella, Ph.D., Professor of Pharmaceutical Sciences & Ophthalmology, University of Colorado, developed functionalized nanoparticles, nanoporous microparticles, microparticles, injectable implants, dendrimers, liposomes, and in situ forming gels for the eye. He is a Fellow of the American Association of Pharmaceutical Scientists (2005) and the Association for Research in Vision and Ophthalmology (2010). He received Distinguished Scientist (2006) Award from the University of Nebraska. Henry F. Edelhauser, Ph.D., Professor of Ophthalmology, Emory University, made pioneering contributions towards transcorneal, transscleral, and suprachoroidal drug delivery to the eye. He is a recipient of the Castroviejo Medal and the Alcon Research Award (1999), American Academy of Ophthalmology Senior Achievement Award (2000), and the Procter Medal (2005) for his outstanding ophthalmic translational research. He served as the president of the Association for Research in Vision and Ophthalmology (1990-91).
Biopharmaceutics. --- Drug development. --- Eye -- Diseases -- Chemotherapy. --- Ocular pharmacology. --- Ophthalmic drugs. --- Ocular pharmacology --- Ophthalmology --- Technology, Pharmaceutical --- Specialty Uses of Chemicals --- Pharmaceutical Preparations --- Investigative Techniques --- Diseases --- Therapeutics --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Actions and Uses --- Dosage Forms --- Methods --- Drug Delivery Systems --- Eye Diseases --- Drug Administration Routes --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Ophthalmology & Optometry --- Ophthalmology. --- Eye --- Ophthalmopharmacology --- Drug effects --- Effect of drugs on --- Medicine. --- Pharmacology. --- Pharmaceutical technology. --- Biomedicine. --- Pharmacology/Toxicology. --- Pharmaceutical Sciences/Technology. --- Pharmacology --- Ophthalmic drugs --- Toxicology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology --- Chemicals --- Poisoning --- Poisons --- Toxicology --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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