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Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions.Key FeaturesComprehensive protocols included for the study of* Steroid kinetics and metabolism* Steroid receptors* Molecular and cellular effects of steroids* Steroid effects on integrated systems

Steroid hormones --- Physiological effect. --- Hormonal steroids --- Hormones --- Steroids

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Can traumatic life events cause depression? Studies generally point to a connection between adverse life events and depression. However, establishing a causal rather than associative connection, the key concern of this book, is more problematic. What neurobiological changes may be induced by stress and depression, and to what extent do these changes correspond? The authors structure their examination around three major themes: the pathophysiological role of stress in depression; whether or not a subtype of depression exists that is particularly stress-inducible; and, finally, how best to diagnose and treat depression in relation to its biological underpinnings.

Depression, Mental --- Stress (Physiology) --- Brain --- Pathogenesis. --- Complications. --- Effect of stress on.