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Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedici

Molecular biology. --- Biochemistry. --- Pathology, Molecular. --- Molecular pathology --- Molecular biology --- Physiology, Pathological --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Composition

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Cytoskeletal proteins. --- Dynein. --- Adenosine triphosphatase --- Microtubules --- Structural proteins --- Proteins

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Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease. Presents a broad-based and up-to date view of dynein mechanics, dysfunction, and diseaseContains approaches from genetics, molecular biology, biochemistry, and biophysics discussedProvides companion website with movies of dynamic cell behaviorIncludes extensive chapters written by leading, global experts.

Cytoskeletal proteins. --- Dynein.

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While many introductory public administration textbooks contain a dedicated chapter on ethics, The Public Administration Profession is the first to utilize ethics as a lens for understanding the discipline. Analyses of the ASPA Code of Ethics are deftly woven into each chapter alongside complete coverage of the institutions, processes, concepts, persons, history, and typologies a student needs to gain a thorough grasp of public service as a field of study and practice. Features include: A significant focus on ‘public interests,’ non-profit management, hybrid-private organizations, contracting-out and collaborations, and public service at the state and local levels. A careful examination the role that religion may play in public servants’ decision-making, as well as the un-ignorable and growing role that faith-based organizations play in public administration and non-profit management at large. End-of-chapter ethics case studies, key concepts and persons, and dedicated ‘local community action steps’ in each chapter. Appendices dedicated to future public administration and non-profit career management, writing successful papers throughout a student’s career, and professional codes of ethics. A comprehensive suite of online supplements, including: lecture slides; quizzes and sample midterm and final examinations for undergraduate and graduate courses containing multiple choice, true-false, identifications, and essay questions; chapter outlines with suggestions for classroom discussion; and suggestions for use of appendices, e.g. how to successfully write a short term paper, a brief policy memo, resume, or a book review.Providing students with a comprehensive introduction to the subject while offering instructors an elegant new way to bring ethics prominently into the curriculum, The Public Administration Profession is an ideal introductory text for public administration and public affairs courses at the undergraduate or graduate level.