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Major depressive disorder (MDD) is a complex and heterogeneous disorder, phenotypically and biologically. MDD may be caused by complex interaction between genes and environment in susceptible individuals. Thus, a combination of certain genetic polymorphism, environmental stress, and personal susceptibility ultimately may induce MDD. Gene-environment interactions in the pathophysiology of MDD lead to advancement in personalized medicine by means of genotyping for inter-individual variability in drug action and metabolism. Gene-environment interactions may explain why some subjects become depressed while others remain unaffected. The aim of this book is to describe current knowledge of MDD from the point of view of neurobiology, molecular genetics and cognition. The authors address a deep understanding of cognitive and neurobiological mechanisms involved in MDD.

Depression, Mental --- Psychological aspects --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Neurosciences --- Bipolar disorder

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This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression, the clinical manifestations, and the development of more effective treatments. This second volume is devoted specifically to clinical and management issues. Readers will find detailed information on a wide range of frequently encountered and more complicated clinical presentations, with examination of risk factors and links to other conditions. Diagnostic aspects, including progress toward biological classification and the role of neuroimaging, are explored. Current trends in therapy are examined at length, drawing on the latest evidence and covering not only antidepressant medications but also the roles of neurostimulation, combined pharmacotherapy and psychotherapy, mindfulness-based cognitive therapy, and complementary and alternative medicine. The companion volume is dedicated to the underlying biomedical and neurobiological basis of depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

Depression, Mental --- Treatment. --- Diagnosis. --- Medicine. --- Neurosciences. --- Neurology. --- Psychiatry. --- Neurobiology. --- Clinical psychology. --- Medicine & Public Health. --- Clinical Psychology. --- Psychology, clinical. --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Neurosciences --- Diseases --- Neurology . --- Psychiatry --- Psychology, Applied --- Psychological tests

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This book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. The concluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.

Molecular biology. --- Neurosciences. --- Laboratory medicine. --- Psychiatry. --- Molecular Medicine. --- Laboratory Medicine. --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Intel·ligència artificial --- Ciència cognitiva --- Mètodes de simulació --- Processament de dades --- Sistemes autoorganitzatius --- Aprenentatge automàtic --- Demostració automàtica de teoremes --- Intel·ligència artificial distribuïda --- Intel·ligència computacional --- Sistemes adaptatius --- Tractament del llenguatge natural (Informàtica) --- Raonament qualitatiu --- Representació del coneixement (Teoria de la informació) --- Sistemes de pregunta i resposta --- Traducció automàtica --- Visió per ordinador --- Xarxes neuronals (Informàtica) --- Xarxes semàntiques (Teoria de la informació) --- Agents intel·ligents (Programes d'ordinador) --- Programació per restriccions --- Vida artificial

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Depression, Mental. --- Depression, Mental --- Pathogenesis. --- Treatment. --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Depressió psíquica --- Etiologia --- Terapèutica --- Depressió mental --- Depressió unipolar --- Psicosi depressiva --- Neurastènia --- Neurosi --- Psicopatologia --- Trastorns afectius --- Depressió psíquica en els adolescents --- Depressió psíquica en els infants --- Distímia --- Trastorn bipolar --- Tristesa --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Medicina clínica --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Quimioteràpia --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Causes de les malalties --- Diagnòstics etiològics --- Etiologia mèdica --- Patogènesi --- Patologia --- Accidents --- Infeccions --- Traumatisme --- Factors de risc en les malalties --- Bipolar disorder

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This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.

Psychiatry --- psychiatrie --- farmacologie