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Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors. This second edition of Dopamine Receptors will be of interest to neurobiologists, pharmacologists and molecular biologists who study the brain, as well as neurologists working on psychiatric diseases.

Dopamine -- Receptors -- Physiological effect. --- Dopamine -- Receptors. --- Dopamine -- Therapeutic use. --- Dopamine --- Receptors, Catecholamine --- Receptors, Dopamine --- Receptors, Biogenic Amine --- Receptors, G-Protein-Coupled --- Receptors, Neurotransmitter --- Receptors, Cell Surface --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Medicine --- Human Anatomy & Physiology --- Neuroscience --- Neurology --- Animal Biochemistry --- Health & Biological Sciences --- Receptors --- Neurotransmitter receptors. --- Receptors. --- Dopamine receptors --- Medicine. --- Human physiology. --- Neurosciences. --- Pharmacology. --- Pharmaceutical technology. --- Neurology. --- Neurobiology. --- Medicine & Public Health. --- Pharmacology/Toxicology. --- Human Physiology. --- Pharmaceutical Sciences/Technology. --- Cell receptors --- Hormone receptors --- Neural receptors --- Neurotransmitter receptors --- Toxicology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Human biology --- Medical sciences --- Physiology --- Human body --- Neurosciences --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Neural sciences --- Neurological sciences --- Nervous system --- Neuropsychiatry --- Toxicology --- Diseases --- Neurology . --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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'Adventures in Criminal Justice Research' teaches students how to analyse issues and use the computer program SPSS for criminal justice research. The book explains with step by step instructions and over 150 screen shots.

Criminal justice, Administration of --- Information storage and retrieval systems --- Data processing. --- Statistical methods. --- Criminal justice, Administration of. --- SPSS (Computer file). --- Administration of criminal justice --- Justice, Administration of --- Crime --- Criminal law --- Criminals --- Law and legislation --- SPSS (Computer file) --- Statistical package for the social sciences

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Physiology of nerves and sense organs --- Human physiology --- Pharmacology. Therapy --- Neuropathology --- neurologie --- farmacie --- farmacologie --- hersenen --- toxicologie --- fysiologie --- neurobiologie

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"New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury"--Publisher's description.

Human medicine

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The ability to obtain health care is fundamental to the security, stability, and well-being of poor families. Government-sponsored programs provide temporary support, but as families leave welfare for work, they find themselves without access to coverage or care. The low-wage jobs that individuals in transition are typically able to secure provide few benefits yet often disqualify employees from receiving federal aid. Drawing upon statistical data and in-depth interviews with over five hundred families in Oregon, Karen Seccombe and Kim Hoffman assess the ways in which welfare reform affects the well-being of adults and children who leave the program for work. We hear of asthmatic children whose uninsured but working mothers cannot obtain the preventive medicines to keep them well, and stories of pregnant women receiving little or no prenatal care who end up in emergency rooms with life-threatening conditions. Representative of poor communities nationwide, the vivid stories recounted here illuminate the critical relationship between health insurance coverage and the ability to transition from welfare to work.

Health care reform. --- Health care reform --- Health insurance --- Health services accessibility --- Health Care Reform --- Interviews as Topic --- Insurance, Health --- Socioeconomic Factors --- Health Services Accessibility --- Oregon --- Social Welfare --- Delivery of Health Care --- Northwestern United States --- Health Planning --- Health Policy --- Data Collection --- Population Characteristics --- Sociology --- Insurance --- Patient Care Management --- Epidemiologic Methods --- Social Sciences --- Health Care Evaluation Mechanisms --- Financing, Organized --- Information Science --- Public Policy --- Health Care Quality, Access, and Evaluation --- Health Care Economics and Organizations --- United States --- Health Care --- Health Services Administration --- Quality of Health Care --- Anthropology, Education, Sociology and Social Phenomena --- Public Health --- North America --- Investigative Techniques --- Social Control Policies --- Economics --- Social Control, Formal --- Americas --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Policy --- Environment and Public Health --- Geographic Locations --- Geographicals --- Access to health care --- Accessibility of health services --- Availability of health services --- Medical care --- Health plans, Prepaid --- Medical care, Prepaid --- Medical insurance --- Prepaid health plans --- Prepaid medical care --- Sickness insurance --- Health reform --- Health system reform --- Healthcare reform --- Medical care reform --- Reform of health care delivery --- Reform of medical care delivery --- Access --- Ambulance service --- Home care services --- Hospitals --- Medically uninsured persons --- Surgical clinics --- Medical policy --- Prospective payment --- Emergency services --- Outpatient services --- Rehabilitation services --- Accessibility, Health Services --- Contraceptive Availability --- Health Services Geographic Accessibility --- Program Accessibility --- Access to Health Care --- Accessibility of Health Services --- Availability of Health Services --- Accessibility, Program --- Availability, Contraceptive --- Health Services Availability --- Medically Underserved Area --- Healthcare Reform --- Health Care Reforms --- Healthcare Reforms --- Reform, Health Care --- Reform, Healthcare --- Reforms, Health Care --- Reforms, Healthcare --- Group Health Insurance --- Health Insurance --- Health Insurance, Voluntary --- Health Insurance, Group --- Insurance, Group Health --- Insurance, Voluntary Health --- Voluntary Health Insurance --- Group Interviews --- Interviewers --- Interviews, Telephone --- Oral History as Topic --- Group Interview --- Interview, Group --- Interview, Telephone --- Interviewer --- Interviews, Group --- Telephone Interview --- Telephone Interviews --- Community Services --- Services, Community --- Community Service --- Service, Community --- Welfare, Social --- Public Assistance --- Factors, Socioeconomic --- High-Income Population --- Inequalities --- Land Tenure --- Standard of Living --- Factor, Socioeconomic --- High Income Population --- High-Income Populations --- Inequality --- Living Standard --- Living Standards --- Population, High-Income --- Populations, High-Income --- Socioeconomic Factor --- Tenure, Land --- Access To Medicines --- Access to Contraception --- Access to Health Services --- Access to Medications --- Access to Therapy --- Access to Treatment --- Contraception Access --- Contraceptive Access --- Medication Access --- Access To Medicine --- Access to Contraceptions --- Access to Medication --- Access to Therapies --- Access to Treatments --- Access, Contraception --- Access, Contraceptive --- Access, Medication --- Contraception, Access to --- Contraceptive Accesses --- Medication Accesses --- Medication, Access to --- Therapy, Access to --- Treatment, Access to --- Social Inequalities --- Social Inequality --- Inequalities, Social --- Inequality, Social