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This book highlights the numerous important properties of neutrophils and their role in various diseases, and as a possible therapeutic target as well. The first chapter briefly discusses the main effector neutrophil functions, which is followed by two chapters discussing the importance of different neutrophil receptors (cannabinoid and Fc?R) and their role in various disease conditions. The fourth chapter discusses the differential expression profile of CD16+CD11b+ on the surface of neutrophils as a tool for the diagnosis of acute infections. The last chapter discusses the physics of the NADPH oxidase system and the use of different chemiluminigenic probes for the detection of various reactive oxygen intermediates of the circulating neutrophils.
Neutrophils. --- Neutrophiles. --- Neutrophilic leucocytes --- Polymorphonuclear leucocytes --- Polynuclear leucocytes --- Granulocytes --- Phagocytes --- Neutrophil Band Cells --- LE Cells --- Leukocytes, Polymorphonuclear --- Polymorphonuclear Leukocytes --- Band Cell, Neutrophil --- Band Cells, Neutrophil --- Cell, LE --- Cells, LE --- LE Cell --- Leukocyte, Polymorphonuclear --- Neutrophil --- Neutrophil Band Cell --- Polymorphonuclear Leukocyte --- Extracellular Traps --- Life Sciences --- Immunology and Microbiology --- Intravascular Immunity --- Pure Immunology
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This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). Section 2 provides recent evidence regarding the role of neutrophils in the pathogenesis as well as a therapeutic target for selected disease conditions such as periodontal diseases, rheumatoid arthritis, and cystic fibrosis. Section 3 describes the anti-inflammatory properties of neutrophils with focus regarding their role in graft versus host disease. This book provides a wider picture with regard to the importance of this immune cell type in various diseases with focus on one of its recently discovered properties, NETs. Therapeutic targets aimed to modulate neutrophil functions might provide novel approaches in the treatment of various diseases of infectious and noninfectious origin.
MEDICAL / Hematology. --- Medicine --- Hematology --- Hemorheology --- Health Sciences
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