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In this volume, a wide-ranging series of reviews reveal how systems biology—a holistic and inter-disciplinary approach requiring the combined talents of biologists, mathematicians, and computer scientists—is changing the face of infectious disease research. Leading experts discuss how the use of high-throughput and computational approaches are generating exciting—and often unexpected—new insights into the microbial-host interactions of a variety of bacterial and viral pathogens, including Salmonella, Yersinia, Mycobacterium, influenza virus, human and simian immunodeficiency virus, and hepatitis C virus. Additional chapters focus on systems approaches to innate immunity, intra- and inter-cellular signaling, biomarker discovery, and the evaluation and rational development of improved vaccines. Systems biology has both been hailed as a paradigm shift that will revolutionize biological science and criticized as overly expensive and complex. While the truth no doubt lies somewhere in between, the approach is yielding increasingly detailed and comprehensive views of biological systems and processes, including those that dictate the host response to infection and disease outcome. Systems Biology of Infectious Disease is highly informative reading for investigators already engaged in systems biology research as well as for those scientists and clinicians who may be seeking an introduction to the field.

Biology. --- Cell physiology. --- Computational biology. --- Systems biology. --- Systems biology --- Computational biology --- Research --- Biology --- Infection --- Biological Science Disciplines --- Bacterial Infections and Mycoses --- Science --- Diseases --- Natural Science Disciplines --- Disciplines and Occupations --- Systems Biology --- Computational Biology --- Biomedical Research --- Communicable Diseases --- Health & Biological Sciences --- Biology - General --- Biological systems. --- Biosystems --- Systems, Biological --- Cell function --- Medicine. --- Immunology. --- Medical microbiology. --- Vaccines. --- Biomedicine. --- Biomedicine general. --- Medical Microbiology. --- Vaccine. --- Biologicals --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- System theory --- Cytology --- Physiology --- Bioinformatics --- Biological systems --- Molecular biology --- Philosophy --- Microbiology. --- Microbial biology --- Microorganisms --- Biomedicine, general. --- Health Workforce --- Medicine --- Pharmacology. --- Biomedical Research. --- Research. --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Biological research --- Biomedical research --- Physiological effect

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Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.