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In the 1950s, psychiatric "miracle drugs" revolutionized the treatment of depression, improving the quality of life of countless patients. Over half a century and millions of prescriptions later, advances in brain structure, neurochemistry, and genetics are providing clues to the mechanisms of depression and pointing to new therapeutic possibilities. Depression and Drugs makes the most of these recent developments, introducing both a neurobehavioral theory of chemical/behavioral interactions and a practical framework for modernizing the conceptualization, assessment, and treatment of depression. Its multidimensional analysis offers insights into the brain structures most affected by the disorder, and the complex phenomena involved in medication. By focusing on cognitive, behavioral, and mood effects as well as brain chemistry, the author identifies false leads that have led to impasses in developing better antidepressants and explains why "mild" cases are often the hardest to treat. These groundbreaking ideas bring readers their closest to scientifically answering the eternal questions How do depressive states form? and How do drugs resolve them? Included in the coverage: Dimensions versus diagnosis in depression research. The experience of the severe depressed state. The componential approach to developing measures of mood and behavior. Testing new hypotheses about chemistry, depression, and drugs. Developing a more effective clinical trial model. Plus appendices detailing emerging assessment methods. This knowledge has the potential for sparking change across a number of fields, making Depression and Drugs of immediate interest to graduate students in psychology and medicine, practicing clinical psychologists, psychiatrists, clinical psychopharmacologists, and basic researchers in psychology and neuropsychopharmacology.
Antidepressants. --- Depression -- Drug therapy. --- Depression, Mental -- Chemotherapy. --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Neuropsychology. --- Depression, Mental. --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Psychology. --- Psychiatry. --- Cognitive psychology. --- Cognitive Psychology. --- Neurophysiology --- Psychophysiology --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Psychology, clinical. --- Consciousness. --- Apperception --- Mind and body --- Perception --- Philosophy --- Psychology --- Spirit --- Self --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Psychology, Cognitive --- Cognitive science
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This brief guide takes current clinical trial protocols to task and replaces them with a contemporary framework for improving next-generation antidepressants and their underlying science. Innovative models are based on a nuanced, neurologically-informed understanding of drug mechanisms and the component cognitive, mood, and behavioral aspects of depression. The book reconceptualizes not only the clinical trial process but the clinical concept of depression itself as essential to bringing pharmaceutical research and development up to date, boosting efficiency and effectiveness, finding new molecules, and reducing waste. Case studies and a review of salient depression scales illustrate the potential benefits of such wide-scale change. Included in the coverage: Why now the need for a new clinical trials model for antidepressants? Aims and basic requirements of clinical trials: conventional and component-specific models. Methods for measuring the components and the profile of drug actions: the multivantaged approach. Achieving the ideal clinical trial: an example of the merged componential and established models. Prediction and shortening the clinical trial. The video clinical trial. Clinical Trials of Antidepressants will interest a varied audience, including clinical investigators, academic and pharmaceutical company scientists, clinical trial organizations, psychiatrists, outpatient physicians, psychotherapists, clinical psychologists, psychology graduate students, medical students, and government agencies such as the FDA.
Models, Biological --- Drug Discovery --- Clinical Trials as Topic --- Antidepressive Agents --- Evaluation Studies as Topic --- Epidemiologic Study Characteristics as Topic --- Investigative Techniques --- Psychotropic Drugs --- Chemistry, Pharmaceutical --- Models, Theoretical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Central Nervous System Agents --- Chemistry --- Epidemiologic Methods --- Pharmacology --- Health Care Evaluation Mechanisms --- Therapeutic Uses --- Public Health --- Quality of Health Care --- Biological Science Disciplines --- Natural Science Disciplines --- Health Care Quality, Access, and Evaluation --- Environment and Public Health --- Disciplines and Occupations --- Pharmacologic Actions --- Health Care --- Chemical Actions and Uses --- Chemicals and Drugs --- Clinical trials --- Antidepressants --- Statistical methods. --- Mathematical models. --- Evaluation. --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Antidepressive agents --- Energizers, Psychic --- Psychic energizers --- Psychotropic drugs --- Depression, Mental --- Clinical medicine --- Human experimentation in medicine --- Chemotherapy --- Research --- Psychology, clinical. --- Health Psychology. --- Health psychology. --- Health psychology --- Health psychology, Clinical --- Psychology, Clinical health --- Psychology, Health --- Salutogenesis --- Clinical psychology --- Medicine and psychology
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In the 1950s, psychiatric "miracle drugs" revolutionized the treatment of depression, improving the quality of life of countless patients. Over half a century and millions of prescriptions later, advances in brain structure, neurochemistry, and genetics are providing clues to the mechanisms of depression and pointing to new therapeutic possibilities. Depression and Drugs makes the most of these recent developments, introducing both a neurobehavioral theory of chemical/behavioral interactions and a practical framework for modernizing the conceptualization, assessment, and treatment of depression. Its multidimensional analysis offers insights into the brain structures most affected by the disorder, and the complex phenomena involved in medication. By focusing on cognitive, behavioral, and mood effects as well as brain chemistry, the author identifies false leads that have led to impasses in developing better antidepressants and explains why "mild" cases are often the hardest to treat. These groundbreaking ideas bring readers their closest to scientifically answering the eternal questions How do depressive states form? and How do drugs resolve them? Included in the coverage: Dimensions versus diagnosis in depression research. The experience of the severe depressed state. The componential approach to developing measures of mood and behavior. Testing new hypotheses about chemistry, depression, and drugs. Developing a more effective clinical trial model. Plus appendices detailing emerging assessment methods. This knowledge has the potential for sparking change across a number of fields, making Depression and Drugs of immediate interest to graduate students in psychology and medicine, practicing clinical psychologists, psychiatrists, clinical psychopharmacologists, and basic researchers in psychology and neuropsychopharmacology.
Philosophy --- Cognitive psychology --- Psychology --- Psychiatry --- Neuropathology --- klinische chemie --- medische psychologie --- psychiatrie --- psychologie --- filosofie --- cognitieve psychologie --- bewustzijn --- neuropsychologie
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This brief guide takes current clinical trial protocols to task and replaces them with a contemporary framework for improving next-generation antidepressants and their underlying science. Innovative models are based on a nuanced, neurologically-informed understanding of drug mechanisms and the component cognitive, mood, and behavioral aspects of depression. The book reconceptualizes not only the clinical trial process but the clinical concept of depression itself as essential to bringing pharmaceutical research and development up to date, boosting efficiency and effectiveness, finding new molecules, and reducing waste. Case studies and a review of salient depression scales illustrate the potential benefits of such wide-scale change. Included in the coverage: Why now the need for a new clinical trials model for antidepressants? Aims and basic requirements of clinical trials: conventional and component-specific models. Methods for measuring the components and the profile of drug actions: the multivantaged approach. Achieving the ideal clinical trial: an example of the merged componential and established models. Prediction and shortening the clinical trial. The video clinical trial. Clinical Trials of Antidepressants will interest a varied audience, including clinical investigators, academic and pharmaceutical company scientists, clinical trial organizations, psychiatrists, outpatient physicians, psychotherapists, clinical psychologists, psychology graduate students, medical students, and government agencies such as the FDA.
Psychology --- medische psychologie --- psychologie --- psychotherapie
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Clinical psychology --- Psychodiagnostics --- Psychotherapy --- Mental Disorders --- Psychological Tests --- Evaluation --- diagnosis
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Psychiatry --- 159.947 --- Affective disorders --- 616.89 --- Disorders, Affective --- Mood disorders --- Psychology, Pathological --- Psychologie van de wil. Wilskracht --- Psychopathologie --- Conferences - Meetings --- 159.947 Psychologie van de wil. Wilskracht
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Depression --- #Lilly --- diagnosis --- DEPRESSION --- diagnosis. --- Diagnosis.
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