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This brief guide takes current clinical trial protocols to task and replaces them with a contemporary framework for improving next-generation antidepressants and their underlying science. Innovative models are based on a nuanced, neurologically-informed understanding of drug mechanisms and the component cognitive, mood, and behavioral aspects of depression. The book reconceptualizes not only the clinical trial process but the clinical concept of depression itself as essential to bringing pharmaceutical research and development up to date, boosting efficiency and effectiveness, finding new molecules, and reducing waste. Case studies and a review of salient depression scales illustrate the potential benefits of such wide-scale change. Included in the coverage: Why now the need for a new clinical trials model for antidepressants? Aims and basic requirements of clinical trials: conventional and component-specific models. Methods for measuring the components and the profile of drug actions: the multivantaged approach. Achieving the ideal clinical trial: an example of the merged componential and established models. Prediction and shortening the clinical trial. The video clinical trial. Clinical Trials of Antidepressants will interest a varied audience, including clinical investigators, academic and pharmaceutical company scientists, clinical trial organizations, psychiatrists, outpatient physicians, psychotherapists, clinical psychologists, psychology graduate students, medical students, and government agencies such as the FDA.

Models, Biological --- Drug Discovery --- Clinical Trials as Topic --- Antidepressive Agents --- Evaluation Studies as Topic --- Epidemiologic Study Characteristics as Topic --- Investigative Techniques --- Psychotropic Drugs --- Chemistry, Pharmaceutical --- Models, Theoretical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Central Nervous System Agents --- Chemistry --- Epidemiologic Methods --- Pharmacology --- Health Care Evaluation Mechanisms --- Therapeutic Uses --- Public Health --- Quality of Health Care --- Biological Science Disciplines --- Natural Science Disciplines --- Health Care Quality, Access, and Evaluation --- Environment and Public Health --- Disciplines and Occupations --- Pharmacologic Actions --- Health Care --- Chemical Actions and Uses --- Chemicals and Drugs --- Clinical trials --- Antidepressants --- Statistical methods. --- Mathematical models. --- Evaluation. --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Antidepressive agents --- Energizers, Psychic --- Psychic energizers --- Psychotropic drugs --- Depression, Mental --- Clinical medicine --- Human experimentation in medicine --- Chemotherapy --- Research --- Psychology, clinical. --- Health Psychology. --- Health psychology. --- Health psychology --- Health psychology, Clinical --- Psychology, Clinical health --- Psychology, Health --- Salutogenesis --- Clinical psychology --- Medicine and psychology

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This brief guide takes current clinical trial protocols to task and replaces them with a contemporary framework for improving next-generation antidepressants and their underlying science. Innovative models are based on a nuanced, neurologically-informed understanding of drug mechanisms and the component cognitive, mood, and behavioral aspects of depression. The book reconceptualizes not only the clinical trial process but the clinical concept of depression itself as essential to bringing pharmaceutical research and development up to date, boosting efficiency and effectiveness, finding new molecules, and reducing waste. Case studies and a review of salient depression scales illustrate the potential benefits of such wide-scale change. Included in the coverage: Why now the need for a new clinical trials model for antidepressants? Aims and basic requirements of clinical trials: conventional and component-specific models. Methods for measuring the components and the profile of drug actions: the multivantaged approach. Achieving the ideal clinical trial: an example of the merged componential and established models. Prediction and shortening the clinical trial. The video clinical trial. Clinical Trials of Antidepressants will interest a varied audience, including clinical investigators, academic and pharmaceutical company scientists, clinical trial organizations, psychiatrists, outpatient physicians, psychotherapists, clinical psychologists, psychology graduate students, medical students, and government agencies such as the FDA.

Psychology --- medische psychologie --- psychologie --- psychotherapie

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Psychiatry --- 159.947 --- Affective disorders --- 616.89 --- Disorders, Affective --- Mood disorders --- Psychology, Pathological --- Psychologie van de wil. Wilskracht --- Psychopathologie --- Conferences - Meetings --- 159.947 Psychologie van de wil. Wilskracht

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Depression --- #Lilly --- diagnosis --- DEPRESSION --- diagnosis. --- Diagnosis.

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