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2020 (3)

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Book
Evaluation of cytotoxicity and cytoprotection : effects of natural toxins
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ISBN: 3036570918 303657090X Year: 2023 Publisher: Basel, Switzerland : MDPI - Multidisciplinary Digital Publishing Institute,

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Abstract

The lifestyle associated with good quality of food is well known for its widely recognized health benefits, especially when rich in bioactive compounds. Reduced risks of some types of cancer and other diseases have been associated with the adoption of such a diet, as have increased antioxidants, inhibitors of lipid peroxidation, decrease of pro-inflammatory cytokine production, etc. The focus of this Special Issue of Toxins was to gather advances related to the cytotoxicity of natural toxins and the potential for the cytoprotection of natural compounds present in food or plants. In this context, this Special Issue of Toxins comprises eight original contributions. Special attention is given to Fridericia chica (Bignoniaceae) leaves grown in Colombia, extract from Polygonum cuspidatum, Artemisia annua and coffee extracts against mycotoxins ́ effects. Studies of mycotoxins in different animal and human cell lines are also presented for zearalenone, beauvericin, α-zearalenol and β-zearalenol, among others.


Book
Toxicological Effects of Mycotoxins on Target Cells
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Mycotoxins are a Public Health concern that in last year have reached the top 10 food and product hazard categories in the Rapid Alert System for Food and Feed (RASFF), with almost six hundred notifications. The toxicological effects of mycotoxins are evaluated through the extrapolation of results from in vivo and in vitro assays. Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. All these studies are key steps for risk assessment and following legislation for mycotoxins. This Special Issue of Toxins comprises 10 original contributions and two reviews. The Issue reports new findings regarding toxic mechanisms, the use of innovative techniques to study the potential toxicity of mycotoxins not only individually but in combination, reflecting a real scenario according to current studies of mycotoxins.


Book
Toxicological Effects of Mycotoxins on Target Cells
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Mycotoxins are a Public Health concern that in last year have reached the top 10 food and product hazard categories in the Rapid Alert System for Food and Feed (RASFF), with almost six hundred notifications. The toxicological effects of mycotoxins are evaluated through the extrapolation of results from in vivo and in vitro assays. Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. All these studies are key steps for risk assessment and following legislation for mycotoxins. This Special Issue of Toxins comprises 10 original contributions and two reviews. The Issue reports new findings regarding toxic mechanisms, the use of innovative techniques to study the potential toxicity of mycotoxins not only individually but in combination, reflecting a real scenario according to current studies of mycotoxins.


Book
Toxicological Effects of Mycotoxins on Target Cells
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

Mycotoxins are a Public Health concern that in last year have reached the top 10 food and product hazard categories in the Rapid Alert System for Food and Feed (RASFF), with almost six hundred notifications. The toxicological effects of mycotoxins are evaluated through the extrapolation of results from in vivo and in vitro assays. Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. All these studies are key steps for risk assessment and following legislation for mycotoxins. This Special Issue of Toxins comprises 10 original contributions and two reviews. The Issue reports new findings regarding toxic mechanisms, the use of innovative techniques to study the potential toxicity of mycotoxins not only individually but in combination, reflecting a real scenario according to current studies of mycotoxins.

Keywords

Medicine. --- Destruxin A --- Bombyx mori --- binding protein --- BmTudor-sn --- Bm12 cell --- Ochratoxin A (OTA) --- human Stem Cells --- mycotoxins --- cells --- cytotoxicity --- cell culture --- T-2 toxin --- HT-2 toxin --- apoptosis --- autophagy --- endophyte --- fungi --- neurotoxin --- lolitrems --- ochratoxin A --- beauvericin --- mixtures --- HepG2 cells --- genotoxicity --- cell cycle --- Fusarium --- Aspergillus --- Penicillium --- Alternaria --- emerging mycotoxin --- in vitro --- IPEC-J2 --- occurrence data --- trichothecene --- biosynthetic pathway --- acetyltransferase --- deacetylase --- deoxynivalenol --- 3-acetyldeoxynivalenol --- isotrichodermol --- isotrichodermin --- differentiated Caco-2 cells --- cell apoptosis --- transcriptome analysis --- hepatocyte --- chicken --- acute toxicity --- combined toxicity --- cell protection --- silibinin --- in silico prediction --- co-culture models --- mycotoxin interaction --- Loewe additivity --- combination index --- isobologram --- Chou-Talalay method --- MixLow --- IPEC-J2 cells --- RNA-seq --- inflammation --- MAPKs --- Destruxin A --- Bombyx mori --- binding protein --- BmTudor-sn --- Bm12 cell --- Ochratoxin A (OTA) --- human Stem Cells --- mycotoxins --- cells --- cytotoxicity --- cell culture --- T-2 toxin --- HT-2 toxin --- apoptosis --- autophagy --- endophyte --- fungi --- neurotoxin --- lolitrems --- ochratoxin A --- beauvericin --- mixtures --- HepG2 cells --- genotoxicity --- cell cycle --- Fusarium --- Aspergillus --- Penicillium --- Alternaria --- emerging mycotoxin --- in vitro --- IPEC-J2 --- occurrence data --- trichothecene --- biosynthetic pathway --- acetyltransferase --- deacetylase --- deoxynivalenol --- 3-acetyldeoxynivalenol --- isotrichodermol --- isotrichodermin --- differentiated Caco-2 cells --- cell apoptosis --- transcriptome analysis --- hepatocyte --- chicken --- acute toxicity --- combined toxicity --- cell protection --- silibinin --- in silico prediction --- co-culture models --- mycotoxin interaction --- Loewe additivity --- combination index --- isobologram --- Chou-Talalay method --- MixLow --- IPEC-J2 cells --- RNA-seq --- inflammation --- MAPKs

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