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Diffusion MRI is a magnetic resonance imaging (MRI) method that produces in vivo images of biological tissues weighted with the local microstructural characteristics of water diffusion, providing an effective means of visualizing functional connectivities in the nervous system. This book is the first comprehensive reference promoting the understanding of this rapidly evolving and powerful technology and providing the essential handbook for designing, analyzing or interpreting diffusion MR experiments.The book presents diffusion imaging in the context of well-established, classical experime

Human anatomy --- Neuropathology --- Diffusion magnetic resonance imaging --- Diffusion Magnetic Resonance Imaging --- Brain --- Brain Diseases --- methods. --- anatomy & histology. --- diagnosis. --- Diffusion magnetic resonance imaging. --- Diffusion-weighted imaging --- Diffusion-weighted magnetic resonance imaging --- Magnetic resonance imaging

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Diffusion imaging is a non-invasive MR technique that is now being used in novel ways to study aspects of white matter anatomy that could never before be investigated in the living brain. The technique therefore has enormous potential for addressing novel research questions in both basic and clinical neuroscience. This book aims to cover the field of diffusion imaging from the fundamental theory to its most cutting-edge applications. It contains sufficient detail to be a reference book for medical physicists, but will also cover fundamental aspects of experimental design and example applications that will be of interest to clinical and basic neuroscientists. Importantly, the book presents diffusion imaging in the context of well-established, classical experimental techniques, so that readers will be able to assess the scope and limitations of the new imaging technology with respect to techniques available previously. Each section includes chapters on methodology (with the more advanced, mathematical material included in appendices for the interested reader), validation of the imaging technology, and application of diffusion imaging to the study of variation and development of normal brain anatomy, and disruption to the white matter in neurological disease or psychiatric disorder. The aim of the book is to become an essential reference text for scientists designing or interpreting diffusion MR experiments.

Human anatomy --- Neuropathology