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In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.

Biomedicine. --- Cancer Research. --- Biochemistry, general. --- Molecular Medicine. --- Cell Biology. --- Medicine. --- Oncology. --- Biochemistry. --- Cytology. --- Médecine --- Cancérologie --- Biochimie --- Cytologie --- Breast -- Cancer -- Chemotherapy. --- Drug resistance in cancer cells. --- Breast --- Drug resistance in cancer cells --- Antineoplastic Agents --- Drug Therapy --- Pharmacology --- Physiology --- Breast Neoplasms --- Drug Resistance, Neoplasm --- Therapeutics --- Neoplasms by Site --- Drug Resistance --- Biological Science Disciplines --- Breast Diseases --- Therapeutic Uses --- Skin Diseases --- Pharmacologic Actions --- Pharmacological Phenomena --- Neoplasms --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Chemical Actions and Uses --- Physiological Phenomena --- Diseases --- Skin and Connective Tissue Diseases --- Chemicals and Drugs --- Phenomena and Processes --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Chemotherapy --- Chemotherapy. --- Antitumor drug resistance --- Cancer drug resistance --- Drug resistance in cancer --- Drug resistance in tumor cells --- Cancer research. --- Molecular biology. --- Cell biology. --- Medicine & Public Health. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Tumors --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Cancer cells --- Oncology  . --- Health Workforce

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DNA-ligand interactions. --- Drug targeting. --- Gene therapy. --- Genetic vectors. --- Liposomes.

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Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field.