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Organic chemistry --- Histology. Cytology --- General biochemistry --- Molecular biology --- Human biochemistry --- RNA (ribonucleic acid) --- medische biochemie --- organische chemie --- biochemie --- cytologie --- genetische manipulatie --- DNA (deoxyribonucleic acid) --- histologie --- moleculaire biologie

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Transcription factors are - in the most common use of the term - proteins that possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes in proximity to the binding site. Transcription factors are the primary interface between the cell and the genome, and in aggregate control not only regulation of transcription but also genome organization, and play a central role in many aspects of physiology and evolution. This book will provide a reference for the major aspects of transcription factor biochemistry, function, and evolution. Contents will range from a general catalogue of known transcription factor classes, origins and evolution of transcription factor types, and mechanisms of interaction with chromatin, the nuclear scaffold, and RNA polymerase.

Organic chemistry --- Histology. Cytology --- General biochemistry --- Molecular biology --- Human biochemistry --- RNA (ribonucleic acid) --- medische biochemie --- organische chemie --- biochemie --- cytologie --- genetische manipulatie --- DNA (deoxyribonucleic acid) --- histologie --- moleculaire biologie

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This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria. .

Pharmacology. Therapy --- Oncology. Neoplasms --- Pathological haematology --- farmacotherapie --- farmacologie --- leukemie --- oncologie --- hematologie --- gentherapie