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F. Stahl B. Hitzmann K. Mutz D. Landgrebe M. Lübbecke C. Kasper J. Walter T. Scheper Transcriptome Analysis.- M. Castro-Melchor H. Le W.-S. Hu Transcriptome Data Analysis for Cell Culture Processes.- Z. P. Gerdtzen Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools.- J. Niklas E. Heinzle Metabolic Flux Analysis in Systems Biology of Mammalian Cells.- J. Schaub C. Clemens H. Kaufmann T. W. Schulz Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data.- M. Berger M. Kaup V. Blanchard Protein Glycosylation and Its Impact on Biotechnology.- P. Hossler Protein Glycosylation Control in Mammalian Cell Culture: Past Precedents and Contemporary Prospects.- U. Jandt A.-P. Zeng Modeling of Intracellular Transport and Compartmentation.- L. Botezatu S. Sievers L. Gama-Norton R. Schucht H. Hauser D. Wirth Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective.

Cells --- Computational Biology --- Vertebrates --- Genetics --- Chordata --- Biology --- Anatomy --- Biological Science Disciplines --- Animals --- Natural Science Disciplines --- Eukaryota --- Organisms --- Disciplines and Occupations --- Genomics --- Mammals --- Cells, Cultured --- Mechanical Engineering --- Engineering & Applied Sciences --- Bioengineering --- Cell culture. --- Genomics. --- Systems biology. --- Genome research --- Genomes --- Research --- Chemistry. --- Biotechnology. --- Biochemistry. --- Cell biology. --- Biochemistry, general. --- Cell Biology. --- Cell biology --- Cellular biology --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Chemical engineering --- Genetic engineering --- Physical sciences --- Composition --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Molecular genetics --- Cultures (Biology) --- Cytology --- Technique --- Cytology.

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Basic Sciences. Biotechnology -- Biotechnology (General). --- Bioengineering. --- Biotechnology.

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Histology. Cytology --- General biochemistry --- Biotechnology --- biochemie --- biotechnologie --- cytologie --- histologie

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Programming --- Distributed operating systems (Computers) --- Systèmes d'exploitation répartis --- Verdeelde besturingssystemen (Computers) --- #TWER:WTCM --- 681.3*D13 --- Concurrent programming --- 681.3*D13 Concurrent programming --- Electronic data processing --- Distributed processing

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Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.