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The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.

Cellular signal transduction. --- Metastasis. --- Metastasis --- Cellular signal transduction --- Biochemical Processes --- Cell Physiological Processes --- Biological Science Disciplines --- Neoplastic Processes --- Natural Science Disciplines --- Biochemical Phenomena --- Neoplasms --- Cell Physiological Phenomena --- Pathologic Processes --- Chemical Processes --- Neoplasm Metastasis --- Signal Transduction --- Physiology --- Chemical Phenomena --- Disciplines and Occupations --- Diseases --- Phenomena and Processes --- Pathological Conditions, Signs and Symptoms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Carcinogenesis --- Research. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Cancer research --- Pathogenesis --- Dissemination --- Medicine. --- Cancer research. --- Molecular biology. --- Oncology. --- Proteins. --- Cytokines. --- Growth factors. --- Cell biology. --- Medicine & Public Health. --- Cancer Research. --- Molecular Medicine. --- Cytokines and Growth Factors. --- Receptors. --- Cell Biology. --- Pathology --- Genetic toxicology --- Cancer invasiveness --- Cancer of unknown primary origin --- Oncology  . --- Cell receptors. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Cellular immunity --- Immune response --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Tumors --- Regulation --- Health Workforce --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.

Chemistry --- General embryology. Developmental biology --- Histology. Cytology --- Molecular biology --- Plant embryology and development --- Animal physiology. Animal biophysics --- Immunology. Immunopathology --- Oncology. Neoplasms --- oncologie --- cytokines --- cytologie --- groeifactoren --- histologie --- moleculaire biologie --- proteïnen