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Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA). Highlights of this book include the discussion of: - novel, promising compounds - concepts of therapy for new/emerging viruses - managing drug resistance - new therapeutic strategies This book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.

Antiviral agents. --- Virus diseases --- Prevention. --- Treatment. --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Antiviral drugs --- Antivirals --- Anti-infective agents --- Virus inhibitors --- Chemotherapy --- Medical virology. --- Microbiology. --- Toxicology. --- Biochemistry. --- Virology. --- Medical Microbiology. --- Pharmacology/Toxicology. --- Medical Biochemistry. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Microbial biology --- Biology --- Microorganisms --- Medical microbiology --- Virology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Toxicology --- Composition --- Medical microbiology. --- Pharmacology. --- Medical biochemistry. --- Microbiology --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Drug effects --- Medical pharmacology --- Drugs --- Pharmacy --- Physiological effect

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Dramatic advances have been made in recent years in the field of redox enzymology which has resulted in an increase of research activities. This volume will cover the recent milestone developments in this field by leading experts, uniting theory and experiment, and selecting contributions to illustrate important aspects of the mechanisms of electron and radical transfer in proteins. Features: A demonstration of the key principles controlling biological redox reactions; Experimental studies of `simple' soluble systems in various enzyme familiies to illustrate concepts in the control of electron transfer reactions; Detail of advances made in membrane electron transfer through structural descriptions of key membrane-embedded proteins; Appeal to those interested in the design and use of redox enzymes, from academics to industrialists.

Enzymology --- Histology. Cytology --- Molecular biology --- Prosthetic groups (Enzymes) --- Oxidation-reduction reaction. --- Biochemistry. --- Biochemistry, general. --- Molecular biology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology