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Structure-Function Relationships of Human Pathogenic Viruses provides information on the mechanisms by which viruses enter the cell, replicate, package their DNA into capsids and mature into new virions. The relation between structural features and the pathogenicity and oncogenicity of some of the most relevant human viral pathogens are demonstrated and the acquisition of defense mechanisms through virus-host interactions are presented. In contrast to textbooks, this volume combines timely research data to provide a holistic view of viral pathogenesis. Furthermore Structure-Function Relationships of Human Pathogenic Viruses illustrates in a single volume the fundamental processes involved in viral life cycles using up-to-date information from research laboratories around the world. Knowledge of these processes is crucial to develop rationales for the design of future drugs. The timeliness of the data and the comprehensive yet concise approach this book takes in order to present the world of viral pathogens should make it a frontrunner in higher education and R&D.

Viruses --- Viral Physiology --- Viral Proteins --- Virus diseases --- Viral proteins --- Viral envelopes --- Maladies à virus --- Virus --- Protéines virales --- Enveloppe virale --- pathogenicity --- physiology --- Pathogenesis --- Pathogenèse --- Biochemistry. --- Medical parasitology. --- Medical virology. --- Medicine. --- Tropical medicine. --- Viral proteins. --- Virus diseases. --- Pathogenic viruses --- Proteins --- Organisms --- Biological Science Disciplines --- Microbiological Phenomena --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- Natural Science Disciplines --- Disciplines and Occupations --- Chemicals and Drugs --- Virus Physiological Phenomena --- Physiology --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Viruses. --- Viral envelopes. --- Pathogenesis. --- Virus Physiological Phenomena. --- Maladies à virus --- Protéines virales --- Pathogenèse --- EPUB-LIV-FT SPRINGER-B --- Parasitology. --- Virology. --- Biomedicine. --- Biochemistry, general. --- Tropical Medicine. --- pathogenicity. --- physiology. --- Diseases, Tropical --- Hygiene, Tropical --- Medicine --- Public health, Tropical --- Sanitation, Tropical --- Tropical diseases --- Medical climatology --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Microbiology --- Composition --- Microbial proteins

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It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors' repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.

Medical microbiology, virology, parasitology --- medische microbiologie --- virologie

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Immunology. Immunopathology --- Oncology. Neoplasms --- Pathology of the circulatory system --- Gastroenterology --- Neuropathology --- Pathology --- immunologie --- neurologie --- pathologie --- oncologie --- cardiologie --- gastro-enterologie