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Excitatory amino acids : clinical results with antagonists
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ISBN: 9780125468206 0125468202 9780080531342 0080531342 9786611033484 1281033480 Year: 1997 Publisher: San Diego, Calif. : Academic Press,

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Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino

Excitatory amino acids
Author:
ISBN: 9780125468206 0125468202 9780080531342 0080531342 Year: 1997 Publisher: San Diego Academic Press

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Abstract

Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. Features include: * Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology * Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists * Reports of potential drugs in early and late clinical stages of development.

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Prospects in aging : the 1992 sandoz lectures in gerontology
Authors: --- --- --- --- --- et al.
ISBN: 012200745X Year: 1993 Publisher: London ; San Diego ; New York Academic press

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