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Background: Obesity and overweight are known risk factors for the development of rheumatic disease. Furthermore, these conditions may negatively impact disease evolution and therapeutic efficacy. Based on earlier research, the cause for these negative effects might be an accumulation of adipokines and pro-inflammatory cytokines in patients with obesity, leading to a chronic inflammatory state of the body. Some studies have evaluated the effects of intentional weight loss on rheumatic joint diseases. A systematic review would provide a more extensive in-depth view on this topic. Methods: We systematically searched in 7 databases (Medline, Embase, CINAHL database by EBSCO, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library) and the Web of Science Core Collection) for relevant articles. Two independent reviewers screened the articles using the predetermined in- and exclusion criteria. Included studies examined patients with chronic i