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Médicament --- drugs --- Animal de laboratoire --- Laboratory animals --- Expérimentation in vivo --- In vivo experimentation --- Bien-être animal --- animal welfare --- Anticorps monoclonal --- monoclonal antibodies --- Vaccin --- Vaccines --- Santé animale --- Animal health --- Santé publique --- public health --- Qualité --- Quality --- Ethics --- Toxicité --- toxicity --- Technique immunologique --- Immunological techniques --- Biological products --- Therapeutic use --- Congresses --- Animal experimentation
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This study focused on the effects of different enriched environments for mice in a number of behavioral and physiological parameters in two routine laboratory testing procedures -- potency testing for tetanus vaccine and stress induced hyperthermia. The variability in the results was studied by calculating and analyzing mean absolute deviations. Mice from enriched conditions weighed more and consumed more food than mice from standard housing conditions. However, mice from enriched conditions lost more body weight after being housed individually. Other physiological parameters showed no differences. Mice from standard conditions were more active in an open field, suggesting a tendency to over-respond to various stimuli in a testing environment. Mice from enriched environments were more tranquil and easier to handle. The enrichment did not influence the variability in any of the parameters measured, although earlier results and results of other authors suggest that the effects on the variability in results are parameter dependent. When enrichment does not influence variability, there is no reason for not introducing cage enrichment and by doing so contributing to the animals' welfare.
Animal. --- Animals. --- Body weight. --- Body-weight. --- Cage. --- Enriched environment. --- Enriched. --- Enrichment. --- Environment. --- Environmental enrichment. --- Environments. --- Field. --- Food. --- Housing conditions. --- Housing. --- Hyperthermia. --- Laboratory. --- Mice. --- Open field. --- Open-field. --- Parameters. --- Physiological. --- Potency. --- Stimuli. --- Stress. --- Variability. --- Variation. --- Weight. --- Welfare.
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