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Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells.   However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.  This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of  mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.   .

Adult stem cells -- Cytology. --- Biology. --- Stem cells. --- Mesenchymal stem cells --- Stem Cell Transplantation --- Cell Transplantation --- Transplantation --- Surgical Procedures, Operative --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Mesenchymal Stem Cell Transplantation --- Biology --- Health & Biological Sciences --- Cytology --- Mesenchymal stem cells. --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Life sciences. --- Biotechnology. --- Cell biology. --- Life Sciences. --- Stem Cells. --- Cell Biology. --- Multipotent stem cells --- Cytology. --- Chemical engineering --- Genetic engineering --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Mesenchymal Stem Cells --- Cell- and Tissue-Based Therapy. --- Mesenchymal Stem Cell Transplantation. --- physiology. --- Transplantation, Mesenchymal Stem Cell --- Stem Cell Transplantation, Mesenchymal --- Therapy, Cell --- Therapy, Tissue --- Cell Therapy --- Tissue Therapy --- Cell and Tissue Based Therapy --- Tissue Therapy, Historical --- transplantation

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This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.

Extracellular matrix. --- Heart --- Cytology. --- Cement substance (Anatomy) --- Ground substance (Anatomy) --- Ground substance (Histology) --- Intercellular matrix --- Interstitial substance --- Matrix, Extracellular --- Connective tissues --- Extracellular space --- Cardiology. --- Biomedical engineering. --- Cell Biology. --- Biomedical Engineering/Biotechnology. --- Cardiac Surgery. --- Surgery. --- Cardiac surgery --- Open-heart surgery --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Internal medicine --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Diseases --- Surgery --- Myocardium --- Extracellular Matrix. --- Extracellular Matrix Proteins. --- cytology. --- physiology. --- Extracelllular Matrix Proteins. --- Extracellular Matrices --- Matrices, Extracellular --- Matrix Proteins, Extracellular --- Proteins, Extracellular Matrix --- Extracellular Traps --- Extracellular Matrix Protein --- Matrix Protein, Extracellular --- Protein, Extracellular Matrix --- Cell biology. --- Cardiac surgery.