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Christopher A. Lipinski: Overview of Hit to Lead: The Medicinal Chemist’s Role from HTS Retest to Lead Optimization Hand Off Jeff W. Paslay • John E. Morin • Richard K. Harrison: High Throughput Screening in the Twenty - First Century Jack Andrew Bikker • Lakshmi S.Narasimhan: Lead Discovery Using Virtual Screening Maurizio Pellecchia: NMR Spectroscopy in Fragment Based Drug Design Kevin D. Freeman-Cook • Daniel W. Kung: Hit Triage – Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery John W. Ellingboe • Adam M. Gilbert: Lead Identification.

Drug development. --- High throughput screening (Drug development). --- Lead -- Diagnostic use. --- Nuclear magnetic resonance spectroscopy. --- Lead --- Drug development --- High throughput screening (Drug development) --- Nuclear magnetic resonance spectroscopy --- Investigative Techniques --- Technology, Pharmaceutical --- Metals, Heavy --- Chemistry, Pharmaceutical --- Spectrum Analysis --- Elements --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Metals --- Pharmacology --- Chemistry Techniques, Analytical --- Chemistry --- Magnetic Resonance Spectroscopy --- Methods --- Drug Discovery --- High-Throughput Screening Assays --- Natural Science Disciplines --- Inorganic Chemicals --- Biological Science Disciplines --- Chemicals and Drugs --- Disciplines and Occupations --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Diagnostic use --- Pharmaceutical chemistry. --- Development of drugs --- Drugs --- New drug development --- Chemistry, Medical and pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Development --- Chemistry. --- Neurosciences. --- Organic chemistry. --- Medicinal chemistry. --- Medicinal Chemistry. --- Organic Chemistry. --- Pharmacy

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"The literary creativity that flowed through Oceania between 1960 and 1980, an era referred to as the "Golden Age" of Pacific writing, is inextricable from the optimism of a decolonizing age. It is also inseparable from the establishment of the University of Papua New Guinea (UPNG) and the University of the South Pacific (USP). Founded expressly to facilitate Pacific independence, these universities allowed local and overseas educators to design progressive literary studies programs that rejected the old Beowulf-to-Brontë model, working instead towards a critical pedagogy of decolonization to instil a Pacific-centred curriculum that approached European modernist texts from Indigenous Pacific and anticolonial perspectives. Modernist Courses in Oceania tells the story of the effects of these reorientations on the literary texts produced during this transformative age of Pacific literature, which saw the publication of internationally recognized Pacific writers such as Albert Wendt, Subramani, Konai Helu Thaman and Marjorie Crocombe. Maebh Long and Matthew Hayward trace the ways in which modernist literature, themes, techniques, and affects, as they were taught at USP and UPNG, were drawn upon by writers from the decolonizing nations in Oceania. In addition, the authors examine the influence of postcolonial African and Caribbean writers as well as the impact of indigenous Pacific oral forms on Oceanic literature. By the end of this era, there was a body of contemporary Pacific writing that could be channelled back into the literary studies curricula, enabling a new generation of Oceanian writers to take a globally mediated Pacific literature as the wellspring of their own inspiration"--

Pacific Island literature (English) --- History and criticism

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How can we best protect the world’s biodiversity in the face of the growing human population? This question is the central theme of contemporary conservation biology. The protection of biodiversity from overuse by fencing it off from the surrounding landscape is one of the conservation tools available to us. Fences have become common features of our environment and firmly entrenched in our lives, as we use them to surround our farms, houses, and anything we want to keep to ourselves or protect. Within the last few hundred years, conservationists have started using fences to protect biodiversity from overuse and poaching, as well as to protect people from wild animals, especially large carnivores and megaherbivores such as elephants and rhinos. The methodologies for, and approaches to, the use of fences by conservationists vary, and range from the intensive fencing practices in places such as South Africa, to the complete avoidance of fences in other places such as parts of East Africa. In other areas such as Australia and New Zealand fences are used, at enormous costs, not to protect biodiversity from people, but to protect vulnerable native species from invasive alien species such as foxes and cats. Some may argue that biodiversity conservation is not possible without fences, while others argue that the fencing in of biodiversity simply creates zoos and restricts evolutionary potential. Fencing for Conservation: Restriction of Evolutionary Potential or a Riposte to Threatening Processes? reviews some of the issues regarding fencing for conservation and summarises the current state of knowledge and practice, describing numerous case studies from around the world. As such it will be of interest to students and researchers of conservation biology, invasion biology, ecology and wildlife management.

Fences -- Environmental aspects. --- Wildlife conservation. --- Fences --- Biodiversity conservation --- Nature --- Earth & Environmental Sciences --- Agriculture --- Ecology --- Agriculture - General --- Environmental aspects --- Effect of human beings on --- Environmental aspects. --- Life sciences. --- Animal ecology. --- Biodiversity. --- Landscape ecology. --- Conservation biology. --- Ecology. --- Environmental management. --- Nature conservation. --- Life Sciences. --- Conservation Biology/Ecology. --- Nature Conservation. --- Environmental Management. --- Animal Ecology. --- Landscape Ecology. --- Garden structures --- Hedges

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How can we best protect the world's biodiversity in the face of the growing human population? This question is the central theme of contemporary conservation biology. The protection of biodiversity from overuse by fencing it off from the surrounding landscape is one of the conservation tools available to us. Fences have become common features of our environment and firmly entrenched in our lives, as we use them to surround our farms, houses, and anything we want to keep to ourselves or protect. Within the last few hundred years, conservationists have started using fences to protect biodiversity from overuse and poaching, as well as to protect people from wild animals, especially large carnivores and megaherbivores such as elephants and rhinos. The methodologies for, and approaches to, the use of fences by conservationists vary, and range from the intensive fencing practices in places such as South Africa, to the complete avoidance of fences in other places such as parts of East Africa. In other areas such as Australia and New Zealand fences are used, at enormous costs, not to protect biodiversity from people, but to protect vulnerable native species from invasive alien species such as foxes and cats. Some may argue that biodiversity conservation is not possible without fences, while others argue that the fencing in of biodiversity simply creates zoos and restricts evolutionary potential. Fencing for Conservation: Restriction of Evolutionary Potential or a Riposte to Threatening Processes? reviews some of the issues regarding fencing for conservation and summarises the current state of knowledge and practice, describing numerous case studies from around the world. As such it will be of interest to students and researchers of conservation biology, invasion biology, ecology and wildlife management.

Nature protection --- General ecology and biosociology --- Animal ethology and ecology. Sociobiology --- Environmental protection. Environmental technology --- biodiversiteit --- dierenecologie --- landschapsecologie --- milieubeleid --- natuurbescherming --- milieubescherming