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Epidemiology of Chronic Disease: Global Perspectives is the most current and authoritative resource on the epidemiology, etiology, pathogenesis, risk factors and preventive factors of over 50 major chronic diseases and conditions. This comprehensive text provides readers with an excellent basis for examining current hypotheses regarding chronic disease epidemiology. Organized into five sections, the text begins with an introductory chapter which examines the new public health environment in which chronic diseases have replaced acute infectious conditions concurrent with improved health care and increasing longevity in many populations of the world. Subsequent sections cover cardiovascular and cerebrovascular diseases, major forms of cancer, diseases of the respiratory tract, metabolic and digestive diseases, musculoskeletal diseases, neurodegenerative diseases, and finally, three infectious diseases that often manifest as chronic conditions. Special sections in each chapter focus on controversial topics that can serve as a launching point for classroom discussion of molecular mechanisms of disease pathogenesis and the relevant epidemiologic issues pertaining to the prevention and control of chronic diseases. Key Features: - Special sections in each chapter focus on controversial topics that can serve as a launching point for classroom discussion of molecular mechanisms of disease pathogenesis and the relevant epidemiologic issues pertaining to the prevention and control of chronic diseases. - Four new chapters on the epidemiology of congestive heart failure, peripheral artery disease and aortic dissection, venous thromboembolism and pulmonary embolism, and sudden cardiac death. - Discussion of new findings, such as the association of post-traumatic stress disorder (PTSD) with suicide and the emerging crisis of antibiotic resistance in tuberculosis and other chronic infections. - Updated epidemiologic findings and references throughout. - Robust instructor’s materials, including an online instructor’s manual with recommended questions and answers for each chapter, slides in PowerPoint format, and a test bank.

Chronic Disease --- Global Health --- Epidemiologic Methods --- Maladies chroniques --- Santé publique --- epidemiology --- statistics & numerical data --- Epidémiologie. --- Chronic diseases --- Epidemiology. --- Epidemiologic Methods. --- epidemiology. --- statistics & numerical data.

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In Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy , a panel of leading experts chronicles the evidence supporting the roleofinflammationinthepathogenesisofmajorchronicdiseasesanddiscusses the current controversy regarding beneficial versus adverse effects of selective cyclooxygenase-2(COX-2)inhibitors.Expertsinmultipledisciplinesofmedical research provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine. The book is broadly divided into fivesections. Webeginwithhistoricalperspectivesonthediscoveryanddev- opment of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, including discussion of risk versus benefit and the potential for development of new compounds with better efficacy and safety in the 21st century. This is followed by a section illuminating the role of inflammatory mechanisms in the pathogenesisofarthritis,cardiovasculardisease,cancer,neurodegenerativedisease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Specific chapters then explore the COX-2 controversy  regarding the potential forpositiveversusnegativeimpactofselectiveCOX-2inhibitorsonthecard- vasculature.Recentfindingssuggestthatcardiovascularriskassociatedwithsome COX-2 inhibitors may not be due to a class effect involving COX-2 inhibition, butratherdependsuponthemolecularstructureofspecificcompoundsthathave independenteffectsunrelatedtoCOX-2andprostaglandinbiosynthesis.Important findingsaredocumentedincancerresearchshowingthatselectiveCOX-2inhibitors havepowerfulantineoplasticeffectsagainstmajorformsofcancer.Aspecialsection exploresthecurrentevidencesupportingtheroleofCOX-2andinflammationinthe development of Alzheimer's disease and other neurodegenerative conditions and thepotentialbenefitofcompoundsthatmodulateCOX-2andotherinflammatory cytokines.Thefinalsectionaddressesnutritionalmodulationofinflammationinthe pathogenesisofchronicdiseaseandthechemopreventivevalueofanti-inflammatory nutraceuticalagents.