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Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.

Neuroimmunology. --- Spinal cord --- Wounds and injuries. --- Neuroimmunomodulation --- Immunology --- Neurosciences --- Spinal Cord Neoplasms. --- Brain Neoplasms. --- Nervous System Diseases --- immunology. --- Benign Neoplasms, Brain --- Brain Neoplasm, Primary --- Brain Neoplasms, Benign --- Brain Neoplasms, Malignant --- Brain Neoplasms, Malignant, Primary --- Brain Neoplasms, Primary Malignant --- Brain Tumor, Primary --- Brain Tumor, Recurrent --- Cancer of the Brain --- Intracranial Neoplasms --- Malignant Neoplasms, Brain --- Malignant Primary Brain Neoplasms --- Neoplasms, Brain --- Neoplasms, Brain, Benign --- Neoplasms, Brain, Malignant --- Neoplasms, Brain, Primary --- Primary Brain Neoplasms --- Primary Malignant Brain Neoplasms --- Primary Malignant Brain Tumors --- Brain Cancer --- Brain Metastases --- Brain Tumors --- Cancer of Brain --- Malignant Primary Brain Tumors --- Neoplasms, Intracranial --- Benign Brain Neoplasm --- Benign Brain Neoplasms --- Benign Neoplasm, Brain --- Brain Benign Neoplasm --- Brain Benign Neoplasms --- Brain Cancers --- Brain Malignant Neoplasm --- Brain Malignant Neoplasms --- Brain Metastase --- Brain Neoplasm --- Brain Neoplasm, Benign --- Brain Neoplasm, Malignant --- Brain Neoplasms, Primary --- Brain Tumor --- Brain Tumors, Recurrent --- Cancer, Brain --- Intracranial Neoplasm --- Malignant Brain Neoplasm --- Malignant Brain Neoplasms --- Malignant Neoplasm, Brain --- Neoplasm, Brain --- Neoplasm, Intracranial --- Primary Brain Neoplasm --- Primary Brain Tumor --- Primary Brain Tumors --- Recurrent Brain Tumor --- Recurrent Brain Tumors --- Tumor, Brain --- Intramedullary Spinal Cord Neoplasms, Primary --- Neoplasms, Spinal Cord --- Primary Intramedullary Spinal Cord Neoplasms --- Primary Spinal Cord Neoplasms, Intramedullary --- Spinal Cord Neoplasms, Benign --- Spinal Cord Neoplasms, Intradural-Extramedullary --- Spinal Cord Neoplasms, Intramedullary --- Spinal Cord Neoplasms, Malignant --- Spinal Cord Neoplasms, Primary Intramedullary --- Tumors, Spinal Cord --- Intradural-Extramedullary Spinal Cord Neoplasms --- Intramedullary Spinal Cord Neoplasms --- Intradural Extramedullary Spinal Cord Neoplasms --- Neoplasm, Spinal Cord --- Spinal Cord Neoplasm --- Spinal Cord Neoplasms, Intradural Extramedullary --- Spinal Cord Tumor --- Spinal Cord Tumors --- Tumor, Spinal Cord --- Medicine—Research. --- Biology—Research. --- Medical genetics. --- Biomedical Research. --- Medical Genetics. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Brain tumors comprise about 5-9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.

Biology --- Human genetics --- Pathological biochemistry --- Human medicine --- medische biochemie --- medische genetica --- biologie --- biomedische wetenschappen