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This book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCRs are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate such specificity? To address this issue, we need to understand how receptors and their signalling partners are synthesized, folded correctly and assembled in order to generate functional complexes. The effects of oligomerization on specificity and efficacy of signal transduction are also discussed. Once receptor complexes are assembled, how are they targeted to different intracellular sites and what controls the trafficking of GPCR signalling complexes? Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCR signalling complexes; how can we manipulate these systems to normalize them functionally?  Therefore, the topics to be covered in this book are: 1) Molecular chaperones involved in regulating (quality control) of GPCR synthesis; 2) Assembly of signalling complexes, or subunits of the complex and their organization; 3) GPCR oligomerization; 4) GPCR trafficking; 5) Problems of trafficking: pharmacological chaperones to the rescue.

Cell organelles -- Periodicals. --- Cytochemistry -- Periodicals. --- G proteins --- Cellular signal transduction --- Receptors, Cell Surface --- Cell Physiological Processes --- Natural Science Disciplines --- Biochemical Processes --- Metabolic Phenomena --- Phenomena and Processes --- Cell Physiological Phenomena --- Chemical Processes --- Membrane Proteins --- Biochemical Phenomena --- Disciplines and Occupations --- Chemical Phenomena --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Receptors, G-Protein-Coupled --- Signal Transduction --- Chemistry --- Metabolism --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Receptors --- Cellular signal transduction. --- Receptors. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Medicine. --- Pharmacology. --- Medical biochemistry. --- Proteins. --- Biomedicine. --- Biomedicine general. --- Pharmacology/Toxicology. --- Medical Biochemistry. --- Membrane proteins --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Toxicology. --- Cell receptors. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Toxicology --- Health Workforce --- Proteins . --- Biomedicine, general. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Clinical biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research